Kyowa Hakko Kogyo Co., Ltd.

Kyowa Hakko Kogyo Kabushiki Kaisha

Kyoichi Fujii

Kentaro Tamaki

Hiroshi Tanaka

Yoshinori Takemoto

Tatsuyuki Hirayama

Seiichi Yada

Nobuo Nakamura

Arihiro Yamada

Toshihiro Yasui

Naoki Naito

Shiro Kudo

Fumio Nishimura

A novel compound, aluminum acetylsalicylate glutaminate having antipyretic, analgesic and anti-inflammatory activities and having little side effects, processes for producing the same and a pharmaceutical composition containing the same are disclosed.

Aluminum acetylsalicylate glutaminate

Disclosed is 3-(3-methyl-3-butenyl)-1, 2, 3, 4, 5, 6-hexahydro-6, 11-dimethyl-8-hydroxy-2, 6-methano-3-benzazocine, a new derivative of benzazocine, which has superior analgesic properties.

Analgesic

6,7-Benzomorphan derivatives, which are useful as unaddictive analgesics, are prepared from aromatic aminoketones through several steps of reactions. Most of the intermediates are new compounds. Process for preparing 2-benzyl-1,2,5,6-tetrahydropyridine derivatives which are known as intermediates for the preparation of 6,7-benzomorphan derivatives is also disclosed.

2-Amino-1,2,3,4-tetrahydronaphthalene derivatives

2-Allyloxy-4-chloro-.beta.-piperidinopropiophenone is prepared by reacting 2-allyloxy-4-chloroacetophenone with piperidine and formaldehyde. 2-Allyloxy-4-chloro-.beta.-piperidinopropiophenone is useful as an antitussive.

2-Allyloxy-4-chloro-acetophenone

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Sakai, Japan

Kyoichi Fujii