Green Peptide Co., Ltd.

Other

Kurume University

Kyogo Itoh

Shionogi Company Limited

Sumitomo Pharmaceuticals Company Limited

Dainippon Sumitomo Pharma Co., Ltd.

Brightpath Biotherapeutics Co., Ltd.

Shigeki Shichijo

Masanobu Nakao

Yasuhisa Imai

Mamoru Harada

Akira Yamada

Shinya Gomi

Masanori Noguchi

Terutada Kobayashi

Takafumi Higuchi

Shintaro Kamizono

Naoko Seki

Ryuya Yamanaka

Hirohisa Kato

The present invention provides a CTL inducer composition which comprises one or more peptides selected from the group consisting of the peptides of SEQ ID NOS: 1 to 27 in the Sequence Listing, and can be used for the treatment or prevention of cancer or a hepatitis C virus-related disease in two or more patient groups selected from the group consisting of an HLA-A2 positive patient group, an HLA-A24 positive patient group, an HLA-A26 positive patient group, and an HLA-A3 supertype positive patient group.

CTL inducer composition

A novel tumor antigen protein and gene therefor, tumor antigen peptides derived from said tumor antigen protein or derivatives thereof as well as medicaments, prophylactics, or diagnostics for tumors using such tumor substances in vitro or in vitro are provided.

Tumor antigen protein SART-3 and tumor antigen peptides thereof

Provided is a squamous cell carcinoma antigen derived peptide which is capable of binding to an HLA-A24 molecule and recognized by the cellular immune system, and a pharmaceutical composition comprising said peptide for the treatment or prevention of squamous cell carcinoma.

Squamous cell carcinoma antigen-derived peptide binding to HLA-A24 molecule

An object of the invention is to provide a peptide derived from a glioma-associated antigen being useful for the specific immunotherapy for glioma patients. The invention provides a KIF-derived peptide which is capable of binding to an HLA-A24 molecule and recognized by the cellular immune system, and a pharmaceutical composition comprising said peptide for the treatment or prevention of glioma.

HLA-A24-binding KIF-derived peptide

A method for treating a prostate cancer, which comprises administering a therapeutically effective amount of a cancer antigen peptide-associated agent and a lower dose of an estramustine or a salt thereof to a patient in need thereof, and a pharmaceutical composition thereof are provided.

Combination therapy of peptide vaccination and estramustine treatment

The object of the invention is to provide an EGFR-derived peptide useful for EGFR-based immunotherapy. The invention provides an EGFR-derived peptide capable of inducing both cellular and humoral immune responses and mutant peptide thereof and a polypeptide comprising said peptide, a nucleic acid molecule encoding the same, and a pharmaceutical composition comprising the same.

Epidermal growth factor receptor-derived peptides

Tumor antigen inducing and/or activating HLA-A2-restricted tumor-specific cytotoxic T lymphocytes that is activated by recognizing HLA-A2 and a tumor antigen peptide, and a peptide or polypeptide derived from the tumor antigen, a polynucleotide encoding the peptide or a complementary strand polynucleotide thereof, a transformant comprising a recombinant vector which comprises the polynucleotide are provided.

Tumor antigen

The present invention relates to a tumor antigen peptide capable of inducing and/or activating HLA-A24-restricted and/or HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes. The present invention also relates to a method of providing a polynucleotide encoding the peptide and a complementary strand thereto, a recombinant vector containing the polynucleotide, a transformant containing the recombinant vectors. The present invention also relates to a method for producing the peptide, an antibody against the peptide, a compound interacting with these entities and a method for screening for the compound, a pharmaceutical composition utilizing these entities, and a means for the diagnosis utilizing these entities.

Growing community of inventors

Saga-ken, Japan

Kyogo Itoh