Qlt Inc.

Kymberley L Sutton

Patricia M Logan

Jeffery Jerome Wheeler

Ljiljana Kojic

Gabriel Bela Kalmar

Methods are provided to specifically modulate the activation of monocytes and/or macrophages. Administration of integrin linked kinase (ILK) blocking agents; compounds that otherwise prevent the binding of natural ILK ligands to ILK; or compounds that prevent expression of, or signaling through ILK exert an anti-inflammatory effect by inhibiting iNOS and COX-2 expression, at the level of transcription by suppressing the activation of NF-&#x3ba;B. The modulation of activation through ILK is used to regulate immune processes at targeted sites, for example to decrease undesirable inflammatory responses.

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Surrey, Canada

Kymberley L Sutton