Amgen Inc.

Cytokinetics, Inc.

Kyle Quasdorf

Sebastien Caille

Bin Peter Quan

Philipp C Roosen

Andrew Cosbie

Xianqing Shi

Zufan Wu

Fang Wang

Lianxiu Guan

Archana Neergunda

Sheng Cui

Ron C Kelly

Henry Morrison

David Pearson

Lingyun Xiao

Evelyn Yanez

Bradley Paul Morgan

Matthew Lynn Peterson

Andrew Thomas Parsons

Michael T Corbett

John T Colyer

Daniel J Griffin

Joanna Robinson

Alisa Golightly

Jaclyn Raeburn

Michal Achmatowicz

Maria Victoria Silva Elipe

Hannah Nguyen

Ari Elizabeth Ericson

James Murray

Alexander Oblezov

Alex Eberlin

Ailsa Golightly

Peter Bin Quan

Provided herein is a process for preparing compound A comprising (a) admixing 2-isopropyl-4-methylpyridin-3-amine (Compound B), or a salt thereof, a first base, and a reactive compound comprising phosgene or a phosgene equivalent in an organic solvent to form 3-isocyanato-2-isopropyl-4-methylpyridine (Compound C); (b) admixing Compound C and 2,6-dichloro-5-fluoronicotinamide (Compound D) to form 2,6-dichloro-5-fluoro-N-((2-isopropyl-4-methylpyridin-3-yl)carbamoyl)nicotinamide (Compound E); and (c) admixing Compound E and a second base to form a product mixture comprising Compound A and the second base. Also provided herein is a process for synthesizing AMG 510 comprising using Compound A prepared according to the disclosed processes

Process for preparing 7-chloro-6-fluoro-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione

Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates. (1)

Synthesis of omecamtiv mecarbil

Provided herein are free base crystalline forms, crystalline salts, and an amorphous salts of omecamtiv mecarbil.

Salts and crystal forms of omecamtiv mecarbil

Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates.

Provided herein are synthetic methods for the preparation of intermediates that are utilized in the synthesis of omecamtiv mecarbil dihydrochloride.

Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates. (I) 

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Thousand Oaks, CA, United States of America

Kyle Quasdorf