Biogen Ma Inc.

Samsung Bioepis

Gloriana Therapeutics, Inc.

Kyle McElearney

Thomas Ryll

William Yang

Yao-Ming Huang

Lia Tescione

James Lambropoulos

An Zhang

Valerie Liu Tsang

Sangil Lee

Dae Sung Lee

Alan Benjamin Gilbert

Rashmi Rohit Kshirsagar

Terrence Michael Dobrowsky

The present disclosure pertains to a mammalian cell culture genetically modified to express, and which expresses, a neublastin antibody polypeptide, or fragment thereof, in the culture, and to a neublastin antibody polypeptide, or fragment thereof, made by a mammalian cell culture genetically modified to express, and which expresses, the neublastin antibody polypeptide, or fragment thereof.

Mammalian cell culture-produced neublastin antibodies

The present invention pertains to a cell culture medium comprising media supplements that are shown to control recombinant protein glycosylation and/or cell culture in a controlled or modulated (shifted) temperature to control recombinant protein glycosylation and/or cell culture with controlled or modulated seed density to control recombinant protein glycosylation, and methods of using thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture.

Control of protein glycosylation by culture medium supplementation and cell culture process parameters

Growing community of inventors

Medford, MA, United States of America

Kyle McElearney