Purdue Research Foundation

Kyle J Wright

David H Thompson

Seok-Hee Hyun

Scott Charles Bolton

Christopher Benjamin

Methods of using grids in connection with suitable microscopy techniques, such as for determining the structure of target compounds including proteins, are disclosed. Said grid comprising a coating modified with one or more capture agents and a deactivating agent.

Grid coatings for capture of proteins and other compounds

Grids comprising a coating modified with one or more capture agents and a deactivating agent are disclosed. Methods of using such grids in connection with suitable microscopy techniques, such as for determining the structure of target compounds including proteins, are also disclosed.

A polyrotaxane containing an affinity binding group has been designed and prepared. The polyrotaxane of the invention can be used for characterization and determination of the three-dimensional structures of biological molecules, such as proteins.

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West Lafayette, IN, United States of America

Kyle J Wright