Vanderbilt University

The United States Government As Represented by the Department of Veterans Affairs

Baxter International Inc.

Baxter Healthcare Sa

Kyle Hocking

Colleen M Brophy

Susan Eagle

Franz Baudenbacher

Richard Boyer

James P Martucci

Jonathan Alan Handler

Joyce Cheung-Flynn

Padmini Komalavilas

Craig L Duvall

Brian Connor Evans

Kevin Sexton

An example method includes (a) generating, via a sensor of a computing device, a signal representing vibrations originating from a blood vessel of a subject, where the vibrations are indicative of heart beats and/or respirations of the subject; (b) using the signal to determine first times elapsed between respective pairs of consecutive heartbeats indicated by the vibrations and/or second times elapsed between respective pairs of consecutive respirations indicated by the vibrations; and (c) using the determined first times elapsed to determine a heart rate variability of the subject and/or the determined second times elapsed to determine a respiration rate variability of the subject.

Non-invasive venous waveform analysis for evaluating a subject

Devices, systems, and methods for monitoring patient hemodynamic status, systemic vascular resistance, reversal of cardiac and respiratory rates, and patient respiratory volume or effort are disclosed. A peripheral venous pressure is measured and used to detect levels, changes, or problems relating to patient blood volume. The peripheral venous pressure measurement is transformed from the time domain to the frequency domain for analysis. A heart rate frequency is identified, and harmonics of the heart rate frequency are detected and evaluated to determine, among other things, hypovolemia or hypervolemia, systemic vascular resistance, and of cardiac and respiratory rates, and patient respiratory volume or effort.

System and method for monitoring and determining patient parameters from sensed venous waveform

The present disclosure relates to compounds comprising (i) an active agent, wherein the active agent includes a charge at a predetermined pH, (ii) a polymer, wherein the polymer includes an opposite charge than the active agent at the predetermined pH; and (iii) a polyplex comprising the peptide and the polymer electrostatically bond together at the predetermined pH. In some embodiments, the active agent is a peptide, such as a peptide comprising MAPKAP kinase II inhibitory peptide, and in some embodiments the peptide includes a cell-penetrating peptide. In further embodiments, the disclosure provides methods for treating a disease or condition by administering a composition according to the present disclosure to a subject in need thereof.

Polyplexes

Aspects of the invention relates to systems and methods for monitoring an intravenous (IV) line functionality of an IV device. In one embodiment, the system includes an IV catheter to be inserted into the vein of the living subject, at least one pressure sensor in fluid communication with the IV catheter to acquire peripheral venous signals; and a processing device. The processing device receives the peripheral venous signals from the pressure sensor, performs a spectral analysis on the peripheral venous signals to obtain a peripheral venous pressure frequency spectrum, and then performs a statistical analysis on amplitudes of peaks of the peripheral venous pressure frequency spectrum to determine an IV line functionality of the IV catheter in real time. When the IV line functionality indicates IV infiltration, the processing device may control the fluid controlling device to stop the fluid flow from the fluid source to the IV catheter.

Intravenous access device detecting intravenous infiltration and in-vein placement

The leading cause of graft failure is the subsequent development of intimal hyperplasia, which represents a response to injury that is thought to involve smooth muscle proliferation, migration, phenotypic modulation, and extracellular matrix (ECM) deposition. Surgical techniques typically employed for vein harvest&#x2014;stretching the vein, placing the vein in low pH, solutions, and the use of toxic surgical skin markers&#x2014;are shown here to cause injury. The invention therefore provides for non-toxic surgical markers than also protect against stretch-induced loss of functional viability, along with other additives. Devices and compositions for reducing physical stress or protecting from the effects flowing therefrom, also are provided.

Methods and compositions for vein harvest and autografting

Aspects of the invention relates to systems and methods for detecting volume status, volume overload, dehydration, hemorrhage and real time assessment of resuscitation, as well as organ failure including but not limited cardiac, renal, and hepatic dysfunction, of a living subject using non-invasive vascular analysis (NIVA). In one embodiment, a non-invasive device, which includes at least one sensor, is used to acquire vascular signals from the living subject in real time. The vascular signals are sent to a controller, which processes the vascular signals to determine at least one hemodynamic parameter, such as the volume status of the living subject. In certain embodiments, the vascular signals are processed by a spectral fast Fourier transform (FFT) analysis to obtain the peripheral vascular signal frequency spectrum, and the volume status of the living subject may be determined by comparing amplitudes of the peaks of the peripheral vascular signal frequency spectrum.

Device and method for hemorrhage detection and guided resuscitation and applications of same

In one aspect, an apparatus for measuring peripheral venous pressure includes a tubing having two ends with one end connectable to a fluid source and the other end connectable to a vein, a fluid controlling device configured to have an on position and an off position, and at least one pressure sensor configured to measure fluid pressures therein. When the fluid controlling device is in the on position, fluid flow in the tubing is allowed to pass through the fluid controlling device, such that the at least one pressure sensor measures both a fluid pressure from the fluid source and a distal venous pressure from the vein. When the fluid controlling device is in the off position, no fluid flow in the tubing is allowed to pass through the fluid controlling device, such that the at least one pressure sensor measures the distal venous pressure from the vein only.

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Nashville, TN, United States of America

Kyle Hocking