R.j. Reynolds Tobacco Company

Nicoventures Trading Limited

Kyle Ford

John-Paul Mua

Barry Bratcher

Joshua D Morton

Thaddeus Jude Jackson

Nicholas Partain

Anthony Richard Gerardi

Samuel Mark Debusk

Margarette Elisa Lovette

Leigh Ann Blevins Joyce

Leigh Hagan

Barry Smith Fagg

Melissa Ann Clark

Gong Chen

Crystal Dawn Hege Byrd

Luis Monsalud

Chelsea Allison Cooke

Terence McGeown

Chelsea Allison Betts

Tiffany Comer

Caroline W Clark

Chelsea Alison Betts

A substrate in beaded form is provided which includes at least one non-tobacco botanical material, or a flavorant, a botanical extract, or both; a binder; an aerosol forming material; optionally, water and a tobacco material; and optionally a filler. The final form of the substrate can be configured for use in aerosol generating components for aerosol delivery devices. Further provided are aerosol generating components and aerosol delivery devices including the substrate in beaded form. Such devices utilize electrically generated heat or combustible ignition sources to heat the substrate, providing an inhalable substance in the form of an aerosol.

Beaded substrates for aerosol delivery devices

The present disclosure provides protein-enriched, tobacco-containing products, suitable for use as oral formulations. Products of the present disclosure typically include at least one tobacco material (e.g., a particulate tobacco material or a tobacco-derived extract), at least one protein-enriched material (e.g., a tobacco-derived protein-enriched material), and at least one sugar alcohol.

Protein-enriched tobacco composition

The disclosure describes methods for the purification of protein-enriched extracts to provide concentrates and isolates and methods for incorporation of such materials into products. The purification methods are adapted for removal of nicotine and may have other benefits, e.g., lightening the color of the protein-enriched extracts. The methods generally include treatment with peracetic acid or hydrogen peroxide and filtrations. A protein composition in the form of a concentrate or isolate is provided, the protein composition including RuBisCO, F2 fraction proteins, or combination thereof extracted from a plant of thespecies, wherein the protein composition is characterized by relatively low nicotine content.

Purification of tobacco-derived protein compositions

The disclosure describes methods for the purification of protein-enriched extracts to provide concentrates and isolates and methods for incorporation of such materials into products. The purification methods are adapted for removal of one or more of ash, metal salts, alkaloids, particulates, heavy metals, and other impurities and/or contaminants from extracts, as well as modifying the sensory characteristics (e.g., odor, color, and/or taste characteristics) of extracts. The methods generally include diafiltration, treatment with functionalized resins, and supercritical extraction. A protein composition in the form of a concentrate or isolate is provided, the protein composition including RuBisCO, F2 fraction proteins, or combination thereof extracted from a plant of thespecies, wherein the protein composition is characterized by one or more of: an ash content of less than about 15% by weight; a nicotine content of less than about 10 μg/g, and a heavy metal content of less than about 60 μg/g.

Tobacco-derived protein compositions

The disclosure describes methods for the purification of protein-enriched extracts to provide concentrates and isolates and methods for incorporation of such materials into products. The purification methods are adapted for removal of, e.g., chlorophyll and may thus provide lightening the color of the protein-enriched extracts. The methods generally include treatment with peracetic acid or hydrogen peroxide and filtrations. A protein composition in the form of a concentrate or isolate is provided, the protein composition including RuBisCO, F2 fraction proteins, or combination thereof extracted from a plant material.

Plant-derived protein purification

The present disclosure describes methods of obtaining and/or deriving proteins from plants of thespecies and methods for incorporation of such proteins into various products. For example, a method for obtaining a protein-enriched material from a plant of thespecies or portion thereof is provided, comprising: extracting one or more proteins from the plant material into a solvent to form a liquid protein-containing extract; separating a solid extracted plant material from the liquid protein-containing extract; clarifying the liquid protein-containing extract to form a clarified protein-containing extract and a solids fraction; and treating the clarified protein-containing extract so as to provide a protein-enriched material comprising at least about 60% protein by weight.

Protein-enriched tobacco-derived composition

Methods for refining crude tobacco seed oils and the refined tobacco seed oils produced by such methods are provided herein. In particular, methods for reducing the amount of free fatty acids in the crude oil, for modifying the color of the crude oil, and for reducing any undesirable taste/odor associated with the crude oil are provided. The present invention further relates to the incorporation and use of such refined oil within various products.

Seed oil refinement

The present disclosure describes methods of obtaining and/or deriving a sugar-enriched extract from plants of thespecies and methods for incorporation of such extracts into various tobacco compositions. One exemplary method for preparing a sugar-enriched extract comprises contactingplant material with a solvent and extracting sugars into the solvent to form a liquid sugar-containing extract; separating a solid extracted plant material from the liquid sugar-containing extract; clarifying the liquid sugar-containing extract to form a clarified sugar-containing extract and a solids fraction; and isolating the liquid sugar-containing extract to provide a sugar-enriched extract comprising a combined weight of fructose and glucose of at least about 10% by dry weight. In certain embodiments, the sugars of the extract comprise at least about 50% by weight fructose.

Sugar-enriched extract derived from tobacco

The disclosure describes methods for the purification of protein-enriched extracts to provide concentrates and isolates and methods for incorporation of such materials into products. The purification methods are adapted for removal of one or more of ash, metal salts, alkaloids, particulates, heavy metals, and other impurities and/or contaminants from extracts, as well as modifying the sensory characteristics (e.g., odor, color, and/or taste characteristics) of extracts. The methods generally include diafiltration, treatment with functionalized resins, and supercritical extraction. A protein composition in the form of a concentrate or isolate is provided, the protein composition including RuBisCO, F2 fraction proteins, or combination thereof extracted from a plant of thespecies, wherein the protein composition is characterized by one or more of: an ash content of less than about 15% by weight; a nicotine content of less than about 10 &#x3bc;g/g; and a heavy metal content of less than about 60 &#x3bc;g/g.

Growing community of inventors

Germanton, NC, United States of America

Kyle Ford