Leland Stanford Junior University

The United States Government As Represented by the Department of Veterans Affairs

Kyle Brewer

Anton Wyss-Coray

Andrew Yang

Provided herein are methods for labeling the proteomes of cells, as well as methods for labeling proteins or populations of proteins produced by cells. In some embodiments, the methods comprise introducing variant aminoacyl-tRNA synthetases and noncanonical amino acids into cells. Also provided herein are polynucleotides encoding variant aminoacyl-tRNA synthetases that recognize noncanonical amino acids. The methods and compositions provided herein are useful for, among other things, identifying target cells and identifying biomarkers of interest.

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Stanford, CA, United States of America

Kyle Brewer