Astex Therapeutics Limited

The Institute of Cancer Research: Royal Cancer Hospital

Cancer Research Technology Limtied

Cancer Research Technology Limited

The Institute of Cancer Research : the Royal Cancer Hospital

Kyla Merriom Grimshaw

David Charles Rees

Martyn Frederickson

Steven John Woodhead

The invention provides a composition comprising (S)2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol, wherein the composition is either substantially free of (R)2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol or the composition contains a mixture of the (S) and (R) enantiomers in which the (S) enantiomer predominates. Also provided are processes for the preparation of the (S)2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol, novel process intermediates and methods for making the novel process intermediates.

Compositions comprising (S)-2-amino-1-(4-chlorophenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol as modulator of protein kinases

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Cambridge, United Kingdom

Kyla Merriom Grimshaw