Korea Institute of Ocean Science & Technology

Other

Chonnam National University

Kyeong Won Lee

Young Jun An

Dong Hyun Lee

Jung Hyun Lee

Geun Joong Kim

Dae Eun Cheong

Hye Ji Choi

Su Kyoung Yoo

Jung-Hyun Lee

Won Kyu Lee

Jae Hong Park

Hyung-Soon Yim

Hyung Soon Yim

Ye Eun Jeong

Kiweon Cha

Jurang Woo

Provided is a polypeptide having FGF2 activity and improved temperature stability and protease resistance. The polypeptide includes at least one substitution selected from a substitution of aspartic acid (D) with glutamic acid (E) at position 28, a substitution of cysteine (C) with isoleucine (I) or leucine (L) at position 78, or a substitution of cysteine (C) with isoleucine (I) or tryptophan (W) at position 96 in SEQ ID NO: 1.

FGF2 polypeptide with improved temperature stability and protease resistance and use thereof

A recombinant vector according to an embodiment of the present invention may produce fibroblast growth factor 19 (FGF19) having enhanced solubility. The synonymous codon substitution variant fibroblast growth factor 19 (scvhFGF19) and chaperone &#x394;ssDsbC may be simultaneously and independently expressed in a host cell into which the recombinant vector is introduced, thereby it is possible to overexpress the fibroblast growth factor 19 in a soluble state.

Recombinant vector and method for producing recombinant fibroblast growth factor 19 using the same

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Busan, South Korea

Kyeong Won Lee