Il Dong Pharmaceutical Co., Ltd.

Kyeong-A Kim

Jung Woo Lee

Gunhee Kim

Jin Hee Lee

Joontae Park

Kyung Mi An

Te-ik Sohn

Changmok Oh

Yearin Jun

Jungho Kim

Hongchul Yoon

Myongjae Lee

Jongmin Yoon

Jaeeun Ryu

Seolhee Lee

Jooyun Lee

Dami Lim

Jinsun Kwon

Ilji Jeong

The present disclosure provides CFTR modulator and phosphodiesterase 4 (PDE4) inhibitor compounds of the formula (Ia): and compositions including said compounds. The compounds can provide functionality for modulating CFTR, methods for treating an eye disease or disorder, and methods for treating CFTR-related indications. The present disclosure also provides methods of using said compounds and compositions for inhibiting PDE4 in a biological system or biological sample, for treating an inflammatory disease or disorder, and for treating other PDE4-related indications. Also provided are methods of preparing said compounds and compositions, and synthetic precursors of said compounds.

Substituted pyrazolo[1,5-a]pyrimidines as CFTR modulators

Growing community of inventors

Hwaseong-si, South Korea

Kyeong-A Kim