Korea Institute of Science and Technology

Ilab

Kye Jung Shin

Eun Joo Roh

Dong Jin Kim

Kyung Il Choi

Hyewhon Rhim

Seon Hee Seo

Hye Jin Chung

Youngsoo Kim

Ae Nim Pae

Yong Seo Cho

Hyunah Choo

Hee Sup Shin

Gyo Chang Keum

Jae Kyun Lee

Yong Koo Kang

Eunice Eun-Kyeong Kim

Key-Sun Kim

Hesson Chung

Ghilsoo Nam

Hoh Gyu Hahn

Dong Yun Shin

Kee Dal Nam

Chan Seong Cheong

Kee Hyun Choi

Tae-Hwe Heo

Yoon Jee Kim

Woong Seo Park

Hye Ran Kim

Yun Suk Lee

Sang Woo Park

Soon Bang Kang

Chi Man Song

Dong Chan Kim

Cheolju Lee

Hyung Kook Lee

The present invention relates to: a 4-benzopyranone derivative and a pharmaceutically acceptable salt, solvate, racemate, or stereoisomer thereof; a composition for preventing, alleviating or treating TNF-related diseases, containing the same as an active ingredient; and a method for treating TNF-related diseases, a reagent composition for inhibiting TNF, and a method for inhibiting TNF, all of which use the same. The compositions can be orally administered so as not to cause injection side effects, do not cause immunological tolerance, and can effectively inhibit a TNF activity by being directly bound to TNF while facilitating co-administering with a conventional oral preparation and dosage control.

Composition for preventing or treating TNF-related diseases, containing novel derivative as active ingredient, and method for inhibiting TNF activity by using same

Disclosed are novel imidazolylalkylcarbonyl derivatives useful as calcium channel modulators and a preparation method of the same. Also disclosed is a method for the treatment of diseases by administering the above compounds based on their inhibitory activity against calcium channel.

Imidazolylalkylcarbonyl derivatives as calcium channel modulators and preparation method thereof

Disclosed are bis(styryl)pyrimidine or bis(styryl)benzene compounds, represented by Chemical Formula 1, pharmaceutically acceptable salts, a method for preparing the same, and a pharmaceutical composition for the prevention and treatment of amyloidosis-associated diseases, comprising the same as an active ingredient. Having the ability to inhibit the deposition of beta amyloid and to reduce the toxicity of beta amyloid, the derivatives can improve learning and memory and can be useful in the prevention and treatment of amyloidosis-associated diseases. 

Bis(styryl)pyrimidine or bis(styryl)benzene compounds, pharmaceutically acceptable salts thereof, preparation method thereof, and pharmaceutical composition for prevention or treatment of diseases featuring amyloids comprising the same as an active ingredient

The present invention relates to pyrazolylmethylamine-piperazine derivatives and their pharmaceutically acceptable salts effective as calcium channel modulators and a method of manufacturing the same. The present invention also relates to the medicinal use of the above compounds as therapeutic treatment of diseases due to their effect as calcium channel modulators.

Pyrazolylmethylamine compounds as calcium channel modulators and preparation method thereof

Disclosed herein are a new phenylacetate derivative represented by Chemical Formula 1 or pharmaceutically acceptable salt thereof, a preparation method thereof, and a composition for prevention or treatment of diseases induced by the activation of T-type calcium ion channels containing the same. The composition containing the phenylacetate derivative according to the present invention effectively inhibits the activation of T-type calcium ion channels and may be useful in the prevention or treatment of diseases such as hypertension, cancer, epilepsy, and neurogenic pains induced by the activation of T-type calcium ion channels. 

Phenylacetate derivatives or pharmaceutically acceptable salts thereof, preparation method thereof and composition for prevention or treatment of diseases induced by activation of T-type calcium ion channel containing the same as an active ingredient

An oxazolinone derivative compound, represented by the general formula I, shows superior herbicidal activity against, especially, dicotyledonous vegetables. It is effective upon applying both before and after the sprouting of vegetables. It is prepared by condensating an .alpha.-amino acid represented by the general formula II with an acid chloride represented by the general formula III, to give an acyl .alpha.-amino acid represented by the following formula IV: reacting the acyl .alpha.-amino acid with acetic anhydride; and dehydrating the resulting adduct: ##STR1## wherein, R represents a lower alkyl group or a phenyl group containing halogen, lower alkyl or trifluoromethyl group; X represents halogen atom, carbomethoxy group, nitro group, or halogen or trifluoromethyl-substituted phenoxy group, being the same or different from one another; A represents nitrogen or carbon atom; and n is an integer of 1 to 3.

Oxazolinone derivatives, process for preparing the same, and use of the

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Seoul, South Korea

Kye Jung Shin