Battelle Memorial Institute

The Brigham and Women's Hospital, Inc.

Kwong-Kwok Wong

Samuel C Mok

James J Thomas

Pak Chung Wong

Harlan P Foote

Jeffrey D Saffer

The present invention is directed to diagnostic methods based upon the expression of the protein prostasin. In particular, it is concerned with assays performed on women to determine their risk of ovarian cancer.

Methods of detecting cancer based on osteopontin

Among the embodiments of the present invention is a system including one or more processors operable to access data representative of a biopolymer sequence of monomer units. The one or more processors are further operable to establish a pattern corresponding to at least one fractal curve and generate one or more output signals corresponding to a number of image elements each representative of one of the monomer units. Also included is a display device responsive to the one or more output signals to visualize the biopolymer sequence by displaying the image elements in accordance with the pattern.

Visualization of information with an established order

Methods of detecting cancer based on prostasin

The present invention is an improved method of making a partially modified PCR product from a DNA fragment with a polymerase chain reaction (PCR). In a standard PCR process, the DNA fragment is combined with starting deoxynucleoside triphosphates, a primer, a buffer and a DNA polymerase in a PCR mixture. The PCR mixture is then reacted in the PCR producing copies of the DNA fragment. The improvement of the present invention is adding an amount of a modifier at any step prior to completion of the PCR process thereby randomly and partially modifying the copies of the DNA fragment as a partially modified PCR product. The partially modified PCR product may then be digested with an enzyme that cuts the partially modified PCR product at unmodified sites thereby producing an array of DNA restriction fragments.

Methods for producing partially digested restriction DNA fragments and

The invention encompasses purified and isolated Salmonella nucleotide fragments, methods of expressing and isolating polypeptides coded for by a Salmonella nucleotide sequence, methods for detecting the presence of Salmonella nucleotide sequences, methods for blocking transcription or translation of Salmonella nucleotide sequences, methods for blocking production or activity of polypeptide sequences from Salmonella nucleotide sequences, DNA chips containing Salmonella nucleotide sequences, and purified polypeptides expressed by Salmonella nucleotide sequences.

Growing community of inventors

Sugar Land, TX, United States of America

Kwong-Kwok Wong