Nitto-Denko Corporation

Allergan, Inc.

Allergan Sales, Inc.

Kwok Yin Tsang

Roshantha A Chandraratna

Wenbin Ying

Hao Bai

Xiaoxia Liu

Smita S Bhat

Santosh C Sinha

Jayasree Vasudevan

John Gaudette

Bharat Majeti

Vidyasagar Pradeep Vuligonda

Lei Yu

Seiji Nukui

Yi Jin

Hai Wang

Haiqing Yin

Richard L Beard

Liming Wang

Ling Li

Janet A Takeuchi

Kenjirou Minomi

Hirokazu Takahashi

Jens Harborth

Roger C Adami

Cima Cina

Thong Huy Vu

Roger Adami

Tien T Duong

Haiqing Yuan

Jihua Liu

Chunfeng Yin

Li Wang

Fusogenic compounds, and compositions and methods of use thereof. The fusogenic compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, compounds, compositions and methods are to provide nanoparticles to incorporate or encapsulate active agents, to deliver and distribute the active agents to cells, tissues, organs, and subjects.

Fusogenic compounds for delivery of biologically active molecules

Ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, the compounds, compositions and methods are to provide nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.

Ionizable compounds and compositions and uses thereof

This invention includes fusogenic compounds, and compositions and methods of use thereof. The fusogenic compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to incorporate or encapsulate active agents, to deliver and distribute the active agents to cells, tissues, organs, and subjects.

This invention includes ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.

This invention provides compounds, compositions and methods for modulating the expression of human p21 using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. A nucleic acid molecule can have a) a polynucleotide sense strand and a polynucleotide antisense strand; b) each strand of the molecule being from 15 to 30 nucleotides in length; c) a contiguous region of from 15 to 30 nucleotides of the antisense strand being complementary to a sequence of an mRNA encoding p21; and d) at least a portion of the sense strand can be complementary to at least a portion of the antisense strand, and the molecule has a duplex region of from 15 to 30 nucleotides in length.

RNA agents for P21 gene modulation

Polymer conjugates characterized in that the backbone of the polymer is an anionic polymer and hydrophobic moieties are covalently attached to the polymer backbone are useful for preparing drug encapsulated polymer hydrotropes and compositions. Such materials are useful in methods for delivering the drug into cells, and for the treatment and alleviation of diseases and disorders such as cancer.

Polymer-based hydrotropes for hydrophobic drug delivery

This invention provides compounds, compositions and methods for modulating the expression of human p21 using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. Provided are a range of siRNA structures, having one or more nucleotides being modified or chemically-modified. Advantageous structures include siRNAs with 2'-deoxy nucleotides located in the seed region, as well as other nucleotide modifications.

RNA interference agents for p21 gene modulation

Described herein are methods of lowering the endotoxin content from a polyanionic polymer conjugate. In particular, methods of reducing the endotoxin content from a polyanionic polymer conjugate that can be useful for a variety of drug delivery applications are described herein.

Reduction of endotoxins from polyanionic polymer conjugates

RNA interference agents for P21 gene modulation

Described herein are processes of making biocompatible water-soluble polymers conjugates. In particular, large scale processes of making poly(L-&#x3b3;-glutamyl-glutamate) conjugates that can be useful for a variety of drug delivery applications are described herein.

Large scale process for preparing poly (glutamyl-glutamate) conjugates

This application relates generally to biocompatible water-soluble polymers with pendant functional groups and methods for making them, and particularly to co-polymer polyglutamate amino acid conjugates useful for a variety of anti-cancer drug delivery applications.

Co-polymer conjugates

This application relates generally to biocompatible water-soluble polymers with pendant functional groups and methods for making them, and particularly to polyglutamate amino acid conjugates that can include a linker to a compound that can include a drug, and their use for a variety of drug delivery applications, e.g., anticancer.

Polymer conjugates with a linker

Compounds of formulas 1 through 17 provided in the specification specifically or selectively inhibit either the cytochrome P450RAI-1 enzyme or the cytochrome P450RAI-2 enzyme.

Compounds having selective cytochrome P450RAI-1 or selective cytochrome P450RAI-2 inhibitory activity and methods of obtaining the same

Compounds of the formula where the variables are as defined in the specification, are useful for preventing or treating emphysema and related pulmonary conditions of mammals and other diseases and conditions which are responsive to RARagonist retinoids, such as skin related diseases, including but not limited to acne and psoriasis.

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Irvine, CA, United States of America

Kwok Yin Tsang