Korea Institute of Science and Technology

S-biomedics

Kwi Deok Park

Dong Keun Han

Sang Heon Kim

Kang Won Lee

Jae-Jin Kim

Sang-Heon Kim

Myoung-Woon Moon

Kwang Ryeol Lee

Seung Ja Oh

Ji Yeon Choi

Chang Hun Kum

Bong Soo Lee

Jong Hee Kang

Thanavel Rajangam

Chul Ho Park

Jong Hoon Choi

Seokheon Hong

Seong Bae Cho

Provided is a method of preparing a three-dimensional cell spheroid, the method including forming the cell spheroid by co-culturing adipose-derived stem cells or mesenchymal stem cells with hepatocytes. According to the cell spheroid prepared by the method, the secretome secreted by the adipose-derived stem cells affects hepatocyte maturation, and therefore, hepatic functions of the finally formed three-dimensional cell spheroid, i.e., organoid, may be enhanced. Further, a composition including a culture medium of the adipose-derived stem cells may prevent or treat liver diseases including hepatitis, hepatotoxicity, cholestasis, fatty liver, etc., and may enhance hepatic functions.

Method of preparing three-dimensional cell spheroid including adipose-derived stem cells and hepatocytes

Provided are an in vitro fibrosis model, a method of preparing the in vitro model, and use of the in vitro model, the in vitro model including a cell cluster differentiated from mesenchymal cells, wherein the cell cluster exhibits pathological characteristics of fibrosis.

In vitro fibrosis model, preparing method therefor, and use thereof

Provided are a three-dimensional (3D) fibroblast cluster, a method of preparing the same, an in vitro 3D skin dermis model including a fibroblast cluster cultured from a fibroblast, and a method of screening a drug by using the in vitro 3D skin dermis model.

Three-dimensional fibroblast aggregate and in vitro 3D skin dermis model comprising same

Disclosed are biomedical implants comprising surface-modified metal particles and biodegradable polymers; its use for suppressing inflammation; and a method for preparing a biomedical material, comprising: (a) modifying surface of basic metal particles with a polymer to obtain surface-modified metal particles; and (b) mixing the surface-modified metal particles with a biodegradable polymer, followed by manufacturing a biodegradable biomedical implant, or coating the resulting mixture on a conventional biomedical implant.

Biomedical implants comprising surface-modified metal particles and biodegradable polymers, its use for suppressing inflammation, and preparation method thereof

Disclosed is nanocoupling of a polymer onto a surface of a metal substrate for improving coating adhesion of the polymer on the metal substrate, and in vivo stability and durability of the polymer. In accordance with the present invention, the polymers can be grafted via a chemical bonding on the surface of the metal substrate by the nanocoupling, by which adhesion, biocompatibility and durability of a polymer-coated layer which is to be formed later on the metal substrate were remarkably improved; therefore, the nanocoupling according to the present invention can be applied to surface modification of a metal implant, such as stents, mechanical valves, and an articular, a spinal, a dental and an orthopedic implants.

Nanocoupling for improvement of coating adhesion of polymer on metal substrates

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Seoul, South Korea

Kwi Deok Park