Atomic Energy Council-institute of Nuclear Energy Research

Kwei-Luen Hsu

Yu-Lung Wu

I-Chung Tang

Te-Sheng Liang

Chang-Mau Sheng

Ching-Jun Liou

Cheng-Fang Hsu

Show-Wen Liu

Cheng-Hsien Lin

Jian-Wen Chen

Jin-Jenn Lin

Jyh-Daw Sheu

A radioactive material containing chitosan for inhibiting cancer and a preparation method thereof are revealed. The adioactive material containing chitosan is formed by using SOCTA chelating agent to connect chitosan and radionuclides such asRe, and Tc-99m etc. The preparation method of the radioactive material containing chitosan includes the steps of: prepare SOCTA-Chitosan compound; and prepare M(radionuclide)-SOCTA-Chitosan compound. By biocompatibility and clotting in alkaline environment of human blood of chitosan, the radioactive material containing chitosan is injected into cancer and staying there for a long time so as to achieve effectively treatment.

Radioactive material containing chitosan for inhibiting cancer and preparation method thereof

A radioactive mixture and a manufacturing method thereof are disclosed. The radioactive mixture (Re-MN/Lipiodol mixture) is formed by chelating reaction of MN series compounds that are amine-amide-disulfide amine quadric-dentate chelate ligands with TcO/or ReO, and then dissolved in Lipiodol. Moreover, theTc/orRe of the TcO/or ReOavoids bone marrow injuries caused by freeY. By the feature of the Lipiodol that stays in liver tumors for a long period, the radioactive mixture is applied to treat liver cancers by injection so that injuries caused by surgical operations can be prevented.Re-MN/Lipiodol is used for liver cancer, breast cancer or other solid tumors treatment. Re-188 MN or Re-188 MN/Lipiodol can be mixed with anticancer drugs, hydrogel, liposome, micelle or other nano-particles to form the multifunctional therapeutic modality.

Radioactive mixture and manufacturing method thereof

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Hsinchu, Taiwan

Kwei-Luen Hsu