Chung Ang University Industry Academic Cooperation

Sungkwang Medical Foundation

Cha University Industry-Academic Cooperation Foundation

Zaram Technology Co., Ltd.

Kwang-Hyun Baek

Jae-Hun Jung

Yun-Hwan Jung

Hong Chang Yeoh

Joon Hyun Baek

Jun-Hyeok Park

So-Ra Kim

Ji-Hye Choi

Da-Hye Lee

Soo-Ji Kang

Soo-Yeon Kim

Seul-Ki Kwon

Provided is an analytical method for providing information necessary for a diagnosis of alcohol use disorder, including measuring (i) an expression level of a gene encoding a JNK or p-JNK protein in a subject's sample, (ii) an expression level of a gene encoding a JNK or p-JNK protein and an expression level of a gene encoding the Elk-1 protein in a subject's sample, or (iii) expression levels of genes encoding JNK, p-JNK, and Elk-1 proteins in a subject's sample, respectively; and a kit for a diagnosis of alcohol use disorder which is used in the analytical method.

Analytic method and kit for diagnosing alcohol use disorders

Provided is an analytical method for providing information necessary for a diagnosis of urolithiasis, including measuring an expression level of a gene encoding a YOD1, USP6, USP19, PSMD14, or USP26 protein in a biological sample from a subject to be diagnosed; and a kit for a diagnosis of urolithiasis which is used in the analytical method.

Analysis method and kit for diagnosis of urolithiasis

The present invention provides an Oct-3/4 protein variant wherein lysine at position 156; lysine at position 286; or lysines at positions 156 and 286 in the Oct-3/4 protein is (are) substituted with arginine. The Oct-3/4 protein variant according to the present invention can inhibit a protein degradation mechanism through ubiquitination, and shows a higher half-life, compared to the wild-type Oct-3/4, thereby exhibiting high stability.

Oct-3/4 variant

The present invention provides a vector library for yeast two-hybrid screening of a deubiquitinating enzyme that binds to a target protein and a method for identifying a deubiquitinating enzyme binding to a target protein using the same. Also, the present invention provides a method for screening an agent having anti-cancer activity targeting the deubiquitinating enzyme USP1, USP7, USP12, or USP49 identified by said identifying method.

Vector library for yeast two hybrid screening and method for identifying deubiquitinating enzyme binding to target protein using same

A direct digital frequency synthesizer and a synthesizing method thereof. The direct digital frequency synthesizer uses a hybrid digital to analog converter, which matches output data of a phase accumulator to a sine wave amplitude using a hybrid DAC, including a non-linear DAC and a linear DAC. The non-linear DAC outputs a direct base point current using some bits of output data of a phase accumulator, causing the linear DAC to output a gradient current based on gradient information generated using other bits of the output data of the phase accumulator. These currents are summed for the analog output.

Direct digital frequency synthesizer using hybrid digital to analog converter and synthesizing method thereof

The present invention relates to a digital to analog converter, to a return-to-zero digital to analog converter with improved wideband characteristics by enabling a return-to-zero output without separate clock and controller, and a converting method thereof. Since the return-to-zero digital to analog converter and the converting method thereof are capable of outputting an RZ output without directly providing a clock signal to an analog circuit by configuring a switch for generating a zero point signal and a differential pipeline for providing a differential signal to control the switch according to input digital data using a differential structure, the converter can provide wideband characteristics and high dynamic performance.

Return to zero digital to analog converter and converting method thereof

The present invention relates to a direct digital frequency synthesizer using a variable sine wave-weighted digital to analog converter with improved size and efficiency and a synthesizing method thereof. The direct digital frequency synthesizer and the synthesizing method thereof are capable of simplifying a configuration for matching output data of a phase accumulator to sine wave amplitude without increase in complexity of a DAC by applying a nonlinear DAC for directly generating a current corresponding to base points with sine weights and a variable sine wave-weighted DAC for generating fine currents to be combined with variable weights based on the base points. Accordingly, it is possible to provide a high quality output, reduce a size and power consumption, and increase a speed.

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Seoul, South Korea

Kwang-Hyun Baek