Yuhan Corporation

Kwang-Hoon Lee

June Hyung Lee

Ju Young Park

Ki Hong Kim

Jong-Seo Lee

Moo Young Song

Eun-Jung Lee

Byung Hyun Choi

Na Rae Lee

Young Bong Park

Eunjeong Jeong

Kyu-Tae Kim

Bong-Kook Ko

Nakho Chang

Sunghyun Choi

Disclosed are a novel antibody specifically binding to the tumor-immunosuppressant, TIGIT (T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif [ITIM] domain) or an antigen-binding fragment thereof, a nucleic acid encoding the antibody or the antigen-binding fragment thereof, a vector and a host cell including the nucleic acid, a method for producing the antibody or the antigen-binding fragment thereof, a pharmaceutical composition containing the antibody or the antigen-binding fragment thereof as an active ingredient, and uses of the pharmaceutical composition. The antibody specifically binding to TIGIT or the antigen-binding fragment thereof and the pharmaceutical composition containing the same as an active ingredient are preferably used for the treatment of cancer or tumors.

Anti-TIGIT antibodies and uses thereof

Growing community of inventors

Gyeonggi-do, South Korea

Kwang-Hoon Lee