Dong-a St Co., Ltd.

Km Transderm Ltd.

Kwang-Ho Cha

Masaoki Goto

Sun-Woo Jang

Hyun-Jung Kim

Chang-Yell Shin

Hae-Sun Kim

Hee Jun Park

Jeong-Soo Kim

Sang-Min Hyun

Sung-Joo Hwang

Chanhyuk Park

Wonkyung Cho

Junsung Park

Donggeon Gu

A percutaneous absorption preparation including donepezil for the treatment of dementia is disclosed. The percutaneous absorption preparation for the treatment of dementia includes a support layer, a drug-containing layer, and a release layer, wherein the drug-containing layer contains donepezil or a pharmaceutically acceptable salt thereof as an active ingredient; monothioglycerol, thiocyanate metal salt (preferably potassium salt) or dimethylthiourea as a stabilizer; and a pressure-sensitive adhesive. Also disclosed is a percutaneous absorption preparation for the treatment of dementia with reduced the formation of donepezil impurities.

Percutaneous absorption preparation comprising stabilized donepezil

A percutaneous absorption preparation is disclosed. The percutaneous absorption preparation contains donepezil for treatment of dementia, wherein the preparation includes: (a) donepezil or its pharmaceutically acceptable salt as active component, (b) propylene glycol monocaprylate as solubilizer, and (c) styrene-isoprene-styrene block copolymer ('SIS') as adhesive. The percutaneous absorption preparation has low skin irritation and high skin penetration.

Percutaneous absorption preparation for treating dementia comprising donepezil

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Seoul, South Korea

Kwang-Ho Cha