Korea Institute of Science and Technology

Dentkist Co. Ltd.

Kwang-Duk Ahn

Dong-Keun Han

Dong Keun Han

Jong-Man Kim

Young-ha Kim

Jin-Hee Jeong

Seo-Young Jeong

Hyun Jung Jung

Kwideok Park

Young Min Ju

There is provided a method of preparing biodegradable dual pore polymer scaffolds, comprising the steps of: maintaining a polymer solution containing a biodegradable polymer, an effervescent mixture of carbonate and organic acid, and solvent at a temperature range of &#x2212;196&#xb0; C. to ambient temperature so as to evaporate the solvent and produce a polymer sample; and foaming the polymer sample in a mixed solution of water and alcohol. According to the present invention, the pore size of the polymer scaffolds can be easily controlled, and biodegradable polymer scaffolds can be more simply prepared compared to conventional methods such as salt leaching technique, phase separation technique or gas foaming technique. Further, since the biodegradable polymer scaffolds prepared according to the present invention have a high surface area and porosity without formation of skin layer, secretion of toxic substances and remnant phenomenon, they can be advantageously used for regenerating almost all living tissues and organs in tissue engineering.

Method of preparing biodegradable dual pore polymer scaffolds for tissue engineering

The invention relates to a photo-cured dental pit and fissure sealant composition for caries prevention: i) based on the multifunctional prepolymer mixture of 2,2-bis-(4-(2-hydroxy-3-methacryloyloxypropoxy)phenyl)propane (&ldquo;Bis-GMA&rdquo;), which has conventionally been used as dental pit and fissure sealant for caries prevention, and a multifunctional prepolymer formed by substituting hydrogen atoms in hydroxyl group with methacrylate groups in the Bis-GMA molecules; and ii) comprising a diluent, an inorganic filler, a photoinitiation system, and other additives. The dental pit and fissure sealant composition of the present invention is based on a multifunctional prepolymer mixture and has better physical and mechanical properties and biocompatibility than a conventional composition based on Bis-GMA only.

Photo-cured dental pit and fissure sealant composition for caries prevention

Biodegradable porous polymer scaffolds for tissue engineering prepared from an effervescent mixture and its preparation

The invention relates to a photopolymerizable composite resin composition for dental restoration i) based on the multifunctional prepolymer mixture of 2,2-bis-(4-(2-hydroxy-3-methacryloyloxypropoxy)phenyl)propane (&ldquo;Bis-GMA&rdquo;) and multifunctional prepolymer formed by substituting hydrogen atoms in hydroxyl group with methacrylate groups in this Bis-GMA molecules, and ii) comprising a diluent, an inorganic filler, a photoinitiation system, and other additives. The photopolymerizable composite resin composition for dental restoration based on multifunctional prepolymer mixture has better physical and mechanical properties and biocompatibility than the conventional composition based on only Bis-GMA itself.

Photopolymerizable composite resin compositions for dental restoration

Novel sulfonated polyethyleneoxide-substituted polymers having improved blood compatibility are provided. The polymers are produced by substituting a polymeric substrate having active sites of amide or acid amide group, such as polyurethane, polyamide and polyacrylamide, with sulfonated polyethyleneoxide [PEO--(SO.sub.3 H).sub.n ]. The polymers according to the present invention are valuable as construction materials of the artificial organs for the circulatory system in contact with blood, such as artificial hearts, artificial blood vessels, artificial kidneys, etc.

Process for the preparation of sulfonated polyethyleneoxide-substituted

Novel sulfonated polyethyleneoxide-substituted polymers having improved blood compatibility are provided. The polymers are produced by substituting a polymeric substrate having active sites of amide or acid amide group, such as polyurethane, polyamide and polyacrylamide, with sulfonated polyethyleneoxide PEO-SO.sub.3 H. The polymers according to the present invention are valuable as construction materials of the artificial organs for the circulatory system in contact with blood, such as artificial hearts, artificial blood vessels, artificial kidneys, etc.

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Seoul, South Korea

Kwang-Duk Ahn