Alcon Universal Ltd.

Alcon Manufacturing, Ltd.

Kwan Y Chan

Mutlu Karakelle

Dyson William Hickingbotham

David E Booth

David A Eister

Gregory S Milios

John W Sheets, Jr

An instrument for positioning an intracorneal optical lens within an intracorneal pocket is disclosed. The instrument generally includes a handle and a cannula associated with and having a distal portion extending from the handle. The cannula is for fluidly coupling to a vacuum source in a first mode of operation and to a reservoir of surgical fluid in a second mode of operation. The distal portion of the cannula is for receiving the lens in a folded position around the distal portion. The distal portion has an aperture for providing vacuum to hold the lens in the folded position in the first mode of operation and for ejecting surgical fluid in an outward direction from the distal portion to help unfold the lens in the second mode of operation. Methods of using the instrument for positioning of an intracorneal optical lens are also disclosed.

Instrument for positioning an intracorneal optical lens

A method for determining the propensity of an intraocular lens material to prevent posterior capsule opacification is disclosed. The method involves contacting a sample of an IOL material having the shape of an IOL optic with collagen to form a contact area, incubating the sample in a liquid composition comprising lens epithelial cells, determining whether lens epithelial cells grow on the collagen in the contact area.

Lens epithelial cell growth assay for intraocular lens materials

The use of HETE derivatives in intraocular surgery (e.g., cataract surgery) is disclosed. The HETE derivatives protect and maintain the corneal endothelium.

Use of hydroxyeicosatetraenoic acid derivatives in intraocular surgery

A method for determining the propensity of an intraocular lens material to prevent posterior capsule opacification is disclosed. The method involves incubating replicate samples of an IOL material with collagen IV, washing off any loosely bound collagen IV. Following the washing step, one sample is counted to determine the amount of collagen IV that remains adhered to the IOL material. A second sample is further processed prior to counting by subjecting it to a desorption step and a further washing step.

Collagen IV adhesion assay for intraocular lens materials

A microsurgical instrument that includes a handle and a dissecting tip coupled to the handle is disclosed. The tip includes a blade having a generally elliptical three-dimensional geometry. The blade may include an edge having a first arc and an opposing second arc. When the instrument is used to form an intracorneal pocket for the implantation of an intracorneal optical lens, the curvature of the first arc allows the edge to dissect a first blind spot of the pocket, and the curvature of the second arc allows the edge to dissect a second blind spot of the pocket. The blade may also be formed with a first depression in its top surface and a second depression in its bottom surface. When the instrument is used to form an intracorneal pocket, the depressions reduce the drag on, and corresponding trauma to, stromal tissue.

Lamellar dissecting instrument

A microsurgical instrument having a handle and a dissecting tip coupled to the handle is disclosed. The handle includes a cannula for transporting surgical fluid. The dissecting tip includes a blade for dissecting tissue and an aperture for delivering the fluid. The instrument may be used to more effectively create an intracorneal pocket for the implantation of an intracorneal optical lens.

A microsurgical forceps having a first handle and a second handle coupled to the first handle at a hinge point is disclosed. The first handle includes a cannula for transporting surgical fluid and a first jaw with an aperture for delivering the fluid. The second handle includes a second jaw for cooperating with the first jaw. The first handle may include a second cannula for fluidly coupling to a vacuum source. The first jaw may also include a second aperture for delivering vacuum. The forceps may be used to more effectively position an intracorneal optical lens in an intracorneal pocket.

Growing community of inventors

Fort Worth, TX, United States of America

Kwan Y Chan