Korea Institute of Science and Technology

Ewha University-Industry Collaboration Foundation

Aminologics Co., Ltd.

Aminolux Co., Ltd.

Green Formula Co., Ltd.

Green of Life Co., Ltd.

Kytecbio Co., Ltd.

Kwan Mook Kim

Youn Soo Sohn

Juyoung Yoon

Lijun Tang

Ah-Young Song

Hyun Jung Park

Chong Ock Lee

Young A Lee

Young-A Lee

Jik Chin

Haofei Huang

Won Woo Nam

Ok S Jung

Sung Sil Lee

Eknath Shirbhate Mukesh

Sun Shin Cha

The present disclosure relates to a composition for cell imaging including a probe compound, and a method of cell-material imaging using the same. The composition for cell imaging and the method of cell-material imaging are provided to image the material in the cell by measuring fluorescence generated by reacting the probe and a material in a cell.

Cell imaging composition and cellular material imaging method using same

The present disclosure relates to a novel probe compound, i.e.,-(ortho-benzophenylaminoalkyl)-phenylboronic acid, or its derivative for a fluorescence and/or circular dichroism (CD) sensor for amine compounds containing aminoalcohols. Also, the present disclosure relates to a simultaneous fluorescence and CD analysis method of of amine compounds containing aminoalcohols using the novel probe compound to obtain concentration and optical purity of the amine compounds.

Probe compounds for amino alcohols, and simultaneous fluorescence and circular dichroism analysis method

The present disclosure relates to a t-butylketone binaphthol derivative and a method of preparing the same, the t-butylketone binaphthol derivative being a high-efficiency chiral extracting agent which has a very high chiral selectivity enabling to extract an amino acid from an aqueous solution phase to an organic layer and to facilitate its hydrolysis, and enabling a continuous reuse of the organic layer.

T-Butylketone binaphthol derivative and method of preparing the same

Disclosed is an alanine racemase chiral binaphthol derivative having the ability to recognize amino alcohols selectively on the basis of chirality and transform amino acids from an L-form into a D-form. Methods for the optical resolution of amino acid or amino alcohol and for the optical transformation of D- and L-forms of amino acids using the binaphthol derivative are also provided.

Alanine racemase chiral binaphthol derivative with powerful hydrogen bond donor, and optical resolution and optical transformation methods using the same

Disclosed herein are novel binaphthol derivatives and methods for the optical resolution of amino acids or amino alcohols and for the optical transformation of D, L-forms of amino acids using the same.

Binaphthol derivatives and their use in optical resolution or optical transformation

Platinum (IV) complexes for oral administration represented by the structural formula ##STR1## where A--A is a symmetrical diamine that can chelate to platinum and is selected from the group consisting of ethylene diamine, t(.+-.)-1,2-diaminocyclohexane, 2,2-dimethyl-1,3-propanediamine, cyclohexane-1,1-dimethaneamine and tetrahydro-4H-pyran-4,4-dimethaneamine; and R is propionyl, butyryl or valeryl. These complexes are useful in the treatment of cancer.

Anticancer (IV) complexes for oral administration and a method of making

Novel platinum complexes wherein malonate derivative is the anion ligand are provided with processes for preparation thereof. The complexes of the present invention have excellent antitumor effect and low toxicity.

Platinum complexes of malonic acid derivatives and process for the

The present invention relates to anti-tumor platinum complexes represented by the general formula I: ##STR1## wherein A is selected from the group consisting of ammine and mondentate primary alkyl- and cycloalkylamines having 1-3 carbon atoms such as methyl, ethyl, n-propyl-, isopropyl- and cyclopropylamines, or the two amine groups may be combined to be a bidentate diamine of the chelating form AA such as ethylenediamine, 1,2-diaminocyclohexane, and 2-hydroxy-1,3-diaminopropane, and X is either vinylene(--CH.dbd.CH--) or ethylene (--CH.sub.2 --CH.sub.2 --) when it is bound to two sulfur atoms in a cyclic form or represents two methyl groups separately bound to each sulfur atom.

Growing community of inventors

Seoul, South Korea

Kwan Mook Kim