Vertex Pharmaceuticals, Inc.

Cyclerion Therapeutics, Inc.

Tisento Therapeutics Inc.

Kwame Wiredu Nti-Addae

Yuegang Zhang

Michael Waldo

Praveen Mudunuri

Mark Strohmeier

Simon Adam O'Neil

John Gregg Van Alsten

Ales Medek

Irina Nikolaevna Kadiyala

Kathy Stavropoulos

Song Xue

Ahmad Hashash

Robert C Livingston

Vasu Sethuraman

Thomas Storz

Bin Song

Mettachit Navamal

Leena Kumari Prasad

Luc J Farmer

Mark Willem Ledeboer

Michael John Boyd

Yi Shi

Valdas Jurkauskas

Patrick Raymond Connelly

Randal Byrn

Majed Fawaz

Dean Shannon

Steven Jones

Sarah Robertson

John P Caesar, Jr

Mohammed Asmal

Wanjung Tsai

Eduard Luss-Lusis

Ping Yin

Hai Miao

Brian McClain

Dainius Macikenas

Sarah Marie Robertson

John P Caesar

Brian R Mcclain

Simon Adam O'neil

Jr John P Caesar

The present disclosure relates to crystalline forms of 8-(2-fluorobenzyl)-6-(3-(trifluoromethyl)-1H-1,2,4-triazol-5-yl)imidazo[1,2-a]pyrazine, depicted below as a compound of Formula (I): which are useful as a stimulator of soluble guanylate cyclase (sGC). The present disclosure also provides pharmaceutically acceptable compositions comprising the crystalline forms and methods of using said compositions in the treatment of various disorders.

Crystalline forms of 8-(2-fluorobenzyl)-6-(3-(trifluoromethyl)-1H-1,2,4-triazol-5-yl)imidazo[1,2-a]pyrazine as sGC stimulators

The present disclosure relates to crystalline solid forms of a stimulator of soluble guanylate cyclase (sGC), Compound I: Also provided herein are methods for the preparation of these solid forms. The invention also relates to pharmaceutical formulations and dosage forms comprising these solid forms and their uses thereof, alone or in combination with one or more additional agents, for treating and/or preventing various diseases or disorders; these diseases or disorders are ones that may benefit from sGC stimulation or from an increase in the concentration of nitric oxide (NO) and/or cyclic guanosine monophosphate (cGMP).

Solid forms of an sGC stimulator

The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of Rand Ris H orH and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. Also within the scope of this invention are methods of making and using the same.

Co-crystals and pharmaceutical compositions comprising the same

Polymorphic forms of Compound (1) or a pharmaceutically acceptable salt thereof, wherein Compound (1) is represented by the following structural formula: include Hydrate 2 of Compound (1), Hydrate 3 of Compound (1), Form A of Compound (1), Form B of Compound (1), Form C of Compound (1), Form D of Compound (1), and amorphous Compound (1). Such polymorphic forms are useful for treating influenza, inhibiting the replication of influenza viruses, or reducing the amount of influenza viruses in a biological sample or in a subject.

Inhibitors of influenza viruses replication

Polymorphic forms of Compound (1) or a pharmaceutically acceptable salt thereof, wherein Compound (1) is represented by the following structural formula: are Form A of HCl salt of Compound (1).&#xbd;HO, Form F of HCl salt of Compound (1).3HO, Form D of HCl salt of Compound (1), Form A of Compound (1), and Form A of tosylate salt of Compound (1). Such polymorphic forms are employed for treating influenza, inhibiting the replication of influenza viruses, or reducing the amount of influenza viruses in a biological sample or in a subject.

The present disclosure relates to co-crystals comprising N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1) and a co-former and methods for their preparation. The present disclosure further relates to pharmaceutical compositions comprising the co-crystal forms, as well as methods of treatment therewith and kits.

Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator

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Tewksbury, MA, United States of America

Kwame Wiredu Nti-Addae