Purdue Research Foundation

Kwaku Kyei-Baffour

Mohamed Seleem

Mingji Dai

Haroon Taj Mohammad

Invasive fungal infections present a formidable global public health challenge due to the limited number of approved antifungal agents and the emergence of resistance to the frontline treatment options, such as fluconazole. Three fungal pathogens of significant concern are, andgiven their propensity to cause opportunistic infections in immunocompromised individuals. This disclosure provides a set of aryl isonitrile compounds that possess broad-spectrum antifungal activity primarily against species ofand. The most potent derivatives are capable of inhibiting growth of these key pathogens at concentrations as low as 0.5 &#x3bc;M. Remarkably, the most active compounds exhibit an excellent safety profile and are non-toxic to mammalian cells even at concentrations up to 256 &#x3bc;M.

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West Lafayette, IN, United States of America

Kwaku Kyei-Baffour