Council of Scientific and Industrial Research

Kushalava Reddy Yempalla

Ram Asrey Vishwakarma

Inshad Ali Khan

Sanjay Rai Kumar

Parvinder Pal Singh

Gurunadham Munagala

Samsher Singh

Sumit Sharma

Umed Singh

Vishwakarma Ram Asrey

Hari Prasad Aruri

Satish Sonbarao Gudup

The present invention relates to new generation of triazole functionality containing 6-nitro-2,3-dihydroimidazooxazole agents for general formula I, their method of preparation and their use as drugs for treatment of tuberculosis, MDR-TB and XDR-TB either alone or in combination with other anti-tubercular agents. In general formula 1, X is selected from a group (CH)or a direct bond, where n is any number from 1-6, Y is selected from O, S or direct bond, Ris selected from the group consisting of H, alkyl, substituted alkyl, aryl, substituted aryl, biaryl, substituted biaryl, heterocyclic and substituted heterocyclic, wherein the substituted heterocyclic is selected from any of the following rings consisting of piperazinyl, morpholinyl, piperidyl, pyridyl, triazolyl, triazinyl, pyrimidinyl, pyridazinyl, oxazolyl, furanyl, benzofuranyl, thiophenyl, pyrrolyl, imidazoyl, thiazoyl, quinolinyl, isoquinolinyl, benzooxazolyl and benzothiazolyl and the substitution on aryl and biaryl is selected from the group consisting of F, CI, Br, I, CF, OCF, OR, NOand alkyl chain from C1 to C14, wherein Ris selected from the group consisting of H, alkyl, phenyl and substituted phenyl. 

Substituted 1,2,3-triazol-1-yl-methyl-2,3-dihydro-2-methyl-6-nitroimidazo[2,1-b]oxazoles as anti-mycobacterial agents and a process for the preparation thereof

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Jammu, India

Kushalava Reddy Yempalla