University of British Columbia

Kush Dalal

Paul Rennie

Artem Tcherkassov

Fuqiang Ban

Kateryna Dunayenko

Anton V Tverdokhlebov

Eric Joseph Jean LeBlanc

Sergiy Babiy

Huifang Li

Evgeniia Bogomol

A compound having the structure of Formula I, wherein A is a substituted or unsubstituted aryl or heteroaryl group, D is a substituted or unsubstituted 5- or 6-membered heteroaryl or heterocyclyl group and E is a substituted or unsubstituted aryl, heteroaryl, cycloalkyl or heterocyclyl group. The compounds are used for the treatment of androgen modulated indications including cancer (prostate, breast, ovarian, endometrial or bladder cancer), hair loss, acne, hirsutism, ovarian cysts, polycystic ovary disease, precocious puberty and age related macular degeneration. The use of the compounds for the manufacture of a medicament for modulating AR activity, a method of treatment using such compounds and a pharmaceutical composition and a commercial package comprising said compounds are also described.

Human androgen receptor DNA-binding domain (DBD) compounds as therapeutics and methods for their use

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Vancouver, Canada

Kush Dalal