Drexel University

Philadelphia Health and Education Corporation

Kurtulus Izzetoglu

Meltem Alkan Izzetoglu

Kambiz Pourrezaei

Banu Onaral

Scott C Bunce

Jay Charles Horrow

Ajit Devaraj

Disclosed are methods and devices for measuring a state of anesthesia in a noninvasive manner. Optical techniques may be used to measure changes in a functional near-infrared (fNIR) signal, where the fNIR signal is received in response to directing wavelengths of light in a near-infrared range on a patient. The optical density change may be used to obtain a change in deoxyhemoglobin (deoxy-Hb) concentration and/or a change in an oxyhemoglobin concentration (oxy-Hb). The changes in the deoxy-Hb and/or the oxy-Hb may then be compared to determine a state of anesthesia. The effect of artifacts (e.g., strong surgery room lighting, patient-table tilting, patient intubation/extubation) on the fNIR signal may be removed using a noise removal algorithm. In selecting the noise removal algorithm, a switching technique may be used to select the component analysis algorithm, such as a principal component analysis (PCA), an independent component analysis (ICA), or the like.

Functional near-infrared spectroscopy as a monitor for depth of anesthesia

Functional near-infrared (fNIR) neuroimaging is used to assess credibility, detect deception, and implement a query methodology for determining deception via neuroimaging. Oxygenation levels of portions of the brain are imaged via fNIR spectroscopy and utilized to determine if the subject is telling a lie or a truth. In an example configuration, oxygenation levels in the inferior and/or middle prefrontal cortical areas of the brain, such as the bilateral dorsolateral prefrontal and/or inferior frontal cortex, are measured to determine if a subject is lying relative to telling the truth. An example system includes a portable, flexible, belt like sensing device that is positioned proximate the subjects scalp. Sensed neural activity is transmitted either through wired or wireless means, to a processor for analysis of the sensed neural activity. The query methodology utilizes an attestation assertion that mitigates variance in brain responses due to the length or form of a question.

Deception detection and query methodology for determining deception via neuroimaging

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Drexel Hill, PA, United States of America

Kurtulus Izzetoglu