Bayer Aktiengesellschaft

Farbenfabriken Bayer Aktiengesellschaft

Kurt Stoepel

Friedrich Bossert

Wulf Vater

Horst Meyer

Egbert Wehinger

Stanislav Kazda

Arend Heise

Robertson Towart

Gerhard Franckowiak

Klaus Schlossmann

Freidrich Bossert

Andreas Knorr

Bodo Junge

Hans-Joachim Kabbe

Heinz Ziemann

Stanislav Kaada

Friedrich Bosseret

Andrea Mayer

Annedore Mayer

Hildegard E Mayer

Stanislay Kazda

The invention relates to optically active 1,4-dihydropyridine compounds of Formulas Ia and Ib as defined hereinabove which are effective for influencing circulation. Also included in the invention are compositions containing said optically active compounds and methods for the use of said compounds and compositions.

Optically active 1,4-dihydropyridine esters useful for treating

The compound,

##STR1## is a vaso-dilator effective in combating hypertension and circulatory disorders.

Isopropyl 2-(3-trifluoromethylphenoxy)-ethyl

The invention relates to 1,4-dihydropyridines as well as methods for the preparation of said 1,4-dihydropyridines and compositions contained therein. The invention also includes the use of said compounds and compositions for influencing circulation.

Vasodilating cyanoalkyl esters of 1,4-dihydropyridines

1,4-Dihydro-2,6-dimethyl-4-(2'-chlorophenyl)-3,5-dicarboxylic

The invention includes new 1,4-dihydropyridazine compounds, compositions containing said 1,4-dihydropyridazine compounds and methods for the use of said compounds and compositions. Also included in the invention are methods for preparing the new 1,4-dihydropyridazine compounds.

1,4-Dihydropyridazine compounds, and their medicinal use

The invention includes, as novel compounds, 1,4-dihydropyridazines and methods for their preparation. Also included are compositions containing said compounds and methods for the use of said compounds and compositions. The compounds of the invention are active as circulation-influencing and spasmolytically active agents.

1,4-Dihydropyridazine compounds

The invention includes new 2-amino-3a,4,5,6-tetrahydro-perimidines and method for their preparation from corresponding racemacic compounds. Also included in the invention are pharmaceutical compositions containing said 2-amino-3a,4,5,6-tetrahydro-perimidines and methods for the use of said compounds and compositions.

2-Amino-3a,4,5,6-tetrahydro-perimidine derivatives and their medicinal

The invention includes novel nitro-substituted 1,4-dihydropyridines useful because of their influence on the circulation. Also included in the invention are methods for the preparation of said novel nitro-substituted 1,4-dihydropyridines, compositions containing them and methods for the use of said compounds and compositions.

Nitro-substituted 1,4-dihydropyridines, processes for _their production

The present invention provides 1,4-dihydropyridine derivatives of the formula in which ##STR1## R represents hydrogen, alkyl, alkenyl, alkoxyalkyl, aryl or aralkyl, the alkyl and aryl groups being optionally substituted,

1,4-Dihydropyridine derivatives substituted in the 2 position, and their

The invention concerns the provision of novel 1,4-dihydropyridine-sugar derivatives and processes for their preparation. The invention also concerns pharmaceutical compositions containing the compounds of the invention and methods for their use. The products of the invention, such as 2-[1,4-dihydro-5-(2-propyl)-oxycarbonyl-2,6-dimethyl-4-m-nitrophenyl-3- pyridylcarbonyloxy]-ethyl .beta.-D-glucopyranoside, are effective for the treatment of circulatory disorders and can be used as antihypertensive agents, vasodilators or coronary therapeutic agents.

1,4-Dihydropyridine-sugar derivatives, and their use as medicaments

The invention includes the provision of 2-alkyleneaminodihydropyridines and salts thereof and are useful, inter alia, as coronary dilators and antihypertensive agents. Also included in the invention are pharmaceutical compositions containing said 2-alkyleneaminodihydropyridines and methods of treatment involving the use of said compounds or compositions.

2-Alkyleneaminodihydropyridines compounds, their production and their

The invention provides a novel compound, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid isopropyl 2-propoxyethyl ester and processes for its preparation. In addition, the invention includes the provision of compositions containing the compound of the invention and methods for treating warm-blooded animals for peripheral perfusion disturbances.

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid

The invention relates to new dihydropyridines which are substituted by an amino group in at least one of the 2- and 6-positions, by a sulphur-containing substituent in the 3-position, by a cyclic substituent in the 4-position and by a carbonyl substituent in the 5-position. The new dihydropyridines are particularly useful as agents which influence the circulatory system. Also included in the invention are procedures for preparation of the new dehydropyridines, compositions containing them and methods for their use.

Sulphur-containing amino-dihydropyridines, and their use as medicants

The isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate demonstrates the unique ability of increasing myocardial perfusion upon oral or intravenous administration. Methods of preparing the compound, its use in coronary conditions and pharmaceutical compositions for effecting that use are disclosed.

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Wuppertal, Germany

Kurt Stoepel