Boehringer Mannheim Gmbh

Kurt Stach

Max Thiel

Egon Roesch

Herbert Berger

Karl Dietmann

Wolfgang Vomel

Wolfgang Kampe

Gisbert Sponer

Wolfgang Schaumann

Wolfgang Bartsch

Rudi Gall

Felix Helmut Schmidt

Winfriede Sauer

Ernst-Christian Witte

Alfred Rhomberg

Rita Hoffmann

Alfred Popelak

Ruth Heerdt

Fritz Wiedemann

Fritz Kaiser

Wolfgang Voigtlander

Erich Fauland

Klaus Hardebeck

Harald Stork

Ansgar Lerch

Elmar Bosies

Herbert Leinert

Androniki Roesch

Hartmut Merdes

Werner Winter

Manfred Hubner

Franz Braun

Klaus Koch

Helmut Weber

New amine derivatives of 4-hydroxy-2,1,3-benzthiadiazoles of the formula: ##STR1## wherein R is straight-chained or branched alkyl and the pharmacologically compatible salts thereof, that are markedly effected as inhibitors of adrenogenic .beta.-receptors and thus useful for the treatment and prophylaxis of cardiac and circulatory diseases.

4-Hydroxy-2,1,3-benzthiadiazole compounds and .beta.-adrenergic method

New aminopropanol compounds of the formula ##STR1## wherein R is lower alkyl, cycloalkyl or alkylthioalkyl,

Aminopropanol compounds and compositions for the treatment of cardiac

Cycloalkano-quinolone derivatives having anti-microbial activity characterized by the formula: ##STR1## wherein one of R.sub.1 and R.sub.2 designates hydrogen, halogen, nitro, amino, hydroxyl, acylamino, acyloxy, alkoxy or aryloxy and the other taken together with R.sub.3 forms an alkylene bridge containing 2 to 6 carbon atoms, X is hydrogen, lower alkyl, which may be substituted by a member of the group consisting of halogen, hydroxyl, acyloxy, alkoxy, aryloxy, aralkyloxy, mercapto, alkylmercapto, arylmercapto, arylsulfonyl, and alkylsulfonyl, or X is unsubstituted alkenyl including alkadienyl, or alkynyl and Y is hydroxyl, amino or lower alkoxy, and the pharmaceutically acceptable salts thereof.

Compositions using cycloalkano-quinolone derivatives and their method of

New N-substituted 1-amino-3-phenoxy-propan-2-ol compounds of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are, individually, hydrogen or, taken together, represent a sulfur linkage, an ethylene radical or a valency bond;

N-substituted 1-amino-3-phenoxy-propan-2-ol compounds and therapeutic

New biguanide compounds of the formula: ##STR1## wherein A is saturated or unsaturated cycloaliphatic hydrocarbyl, and the physiologically compatible salts thereof; display outstanding anti-diabetic effectiveness in the treatment of diabetes mellitus, without showing the typical side effects of biguanide treatment, viz., lactacidosis.

Biguanide compounds and anti-diabetic compositions

Nitroimidazolyl-s-triazolo[4,3-b]pyridazines of the formula: ##STR1## wherein R is hydrogen or lower alkyl optionally substituted in the 2-position by hydroxyl or by lower acyloxy or lower alkoxy; A is hydrogen, halogen, azido, cyano; lower alkyl alkoxy, alkylthio, alkylsulfonyl, carboxyl; lower alkoxycarbonyl, lower alkoxycarbonimidoyl; or hydrazino, carbamoyl, amidino or a carboximidohydrazide group optionally substituted by one or two lower acyl, alkyl or cycloalkyl radicals; or A is a radical of the formula: ##STR2## wherein R.sub.1 and R.sub.2 are, individually, hydrogen or a number of organic radicals or, taken together, can be an alkylene bridge; and R.sub.3 is hydrogen or lower alkyl; or, together with R.sub.2, R.sub.3 can form an alkylene bridge; n is 0 or 1; And the pharmaceutically compatible thereof, possess high in vivo effectiveness as antimicrobials.

Nitroimidazolyl-triazolo-pyridazine compounds

New N-substituted 1-amino-3-phenoxy-propan-2-ol compounds of the formula: ##EQU1## wherein R.sub.1 and R.sub.2 are, individually, hydrogen or, taken together, represent a sulfur linkage, an ethylene radical or a valency bond;

New 1-[3-(naphth-1-yloxy)-2-hydroxypropyl]-piperazine compounds of the formula: ##STR1## and the pharmacologically compatible salts thereof are outstandingly effective in lowering blood pressure and are thus useful as anti-hypertensive agents.

1-[3-(Naphth-1-yloxy)-2-hydroxypropvl]-piperazine compounds and

New 1-[3-naphth-1-yloxy)-propyl]-piperazine compounds of the formula: ##STR1## wherein X is hydrogen or methoxy; And the pharmacologically compatible salts thereof; Are outstandingly effective in lowering blood pressure and are thus useful as anti-hypertensive agents.

1-[3-(Naphth-1-yloxy)-propyl]-piperazine compounds and therapeutic

New indole derivatives of the formula ##STR1## wherein R.sub.1 and R.sub.2, which may be the same or different, are hydrogen or halogen or lower alkyl or, taken together, represent a --CH=CH-CH=CH- bridge, with the proviso that R.sub.1 and R.sub.2 are not both hydrogen, and wherein, when R.sub.2 is halogen or alkyl, R.sub.1 can also be alkoxy; Are outstandingly effective in blood sugar lowering action in mammals.

2-Hydroxymethyl indole compounds and blood sugar lowering compositions

New cyclopenteno-quinolone derivatives of the formula ##SPC1## Wherein

Cyclopenteno-3-carboxyl-4-quinolone derivatives and their bacteriostatic

New 3-alkyl-4-sulfamoyl-aniline compounds of the formula ##SPC1## Wherein

3-Alkyl-4-sulfamoyl-aniline therapeutic compositions

Nitroimidazolyl-s-triazolo[4,3-b]pyridazines of the formula: ##SPC1## Wherein R is hydrogen or lower alkyl optionally substituted in the 2-position by hydroxyl or by lower acyloxy or lower alkoxy; A is hydrogen, halogen, azido, cyano; lower alkyl, alkoxy, alkylthio, alkylsulfonyl, carboxyl; lower alkoxycarbonyl, lower alkoxycarbonimidoyl; or hydrazino, carbamoyl, amidino or a carboximidohydrazide group optionally substituted by one or two lower acyl, alkyl or cycloalkyl radicals; or A is a radical of the formula: ##EQU1## wherein R.sub.1 and R.sub.2 are, individually, hydrogen or a number of organic radicals or, taken together, can be an alkylene bridge; and R.sub.3 is hydrogen or lower alkyl; or, together with R.sub.2, R.sub.3 can form an alkylene bridge; n is 0 or 1; And the pharmaceutically compatible thereof, possess high in vivo effectiveness as antimicrobials.

Combating bacteria with nitroimidazolyl-triazolo-pyridiazine compounds

New heterocyclic-substituted nebularin compounds of the formula: ##SPC1## Wherein

Growing community of inventors

Mannheim-Waldhof, Germany

Kurt Stach