Baxter International Inc.

Baxter Healthcare Sa

Takeda Pharmaceutical Company Limited

Baxalta Gmbh

Boehringer Ingelheim International Gmbh

Kurt Schnecker

Peter Turecek

Nebojsa Nikolic

Klaus Tschetschkowitsch

Michaela Frey

Wolfgang Grabmayer

Thomas Jancik

Matthias Fried

Barbara Riegler

Alma Kasapovic

Eva Haidweger

Hans-Peter Schwarz

Peter Matthiessen

Traute Mundorf

Long-term stable pharmaceutical formulations of lyophilized recombinant von-Willebrand Factor (rVWF) and methods for making and administering said formulations are described.

Lyophilized recombinant VWF formulations

The present invention provides long-term stable pharmaceutical formulations of recombinant von-Willebrand Factor (rVWF) and methods for making and administering said formulations.

Recombinant VWF formulations

A method is disclosed for filtering a protein in a liquid mixture in a manner that does not substantially damage or otherwise limit the recovery of the protein in the filtration filtrate. The method generally includes passing a liquid mixture containing a protein (e.g., an aqueous vWF mixture) through a filter while applying a counter pressure to the liquid mixture filtrate to accurately reduce and control the pressure differential across the filter. The disclosed method has the advantage that relatively high filtration flow rates can be achieved at relatively low pressure differentials, in contrast to high pressure differentials, which actually reduce the filtration flow rate of protein liquid mixtures. Further, the method can recover substantially all of the protein that is initially present in the liquid mixture.

Counter-pressure filtration of proteins

This invention relates to pharmaceutical preparations for topical application containing one or more stabilized therapeutically active proteins and optional conventional excipients, carriers and additives, and a process for preparing pharmaceutical preparations of this kind and the use of physiologically acceptable hydrophobic substances for stabilizing proteins.

Stabilization of therapeutically active proteins in pharmaceutical

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Vienna, Austria

Kurt Schnecker