Merckle Gmbh

Kurt Rauchle

Gunter Metz

Pyare L Seth

Manfred Erdmann

Otto Von Stetten

Franz Schmid

Novel diethylene glycol monoester of antirheumatically effective acids, e.g., lonazolac and diclofenac and others are disclosed which have inflammation inhibitory properties superior to the corresponding acid base forms. They may be produced through direct esterification without elimination of water and are suitable in the fight against diseases of the rheumatic complex.

Diethylene glycol monoester derivatives, compositions and therapeutic use

Disclosed are aqueous, stable, relatively concentrated solutions of diclofenac, which contain a mixture of propylene glycol and polyethylene glycol in defined quantitative proportions. The solutions preferably contain a local anesthetic such as lidocaine and a reducing agent as stabilizer.

Liquid diclofenac preparations

At least one barbiturate or one of its pharmaceutically acceptable salts is combined with cinnarizine or flunarizine or one of their pharmaceutically acceptable salts to provide a hypnotic requiring lower dosages of barbiturates to produce the same effect as the barbiturate alone.

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Blaubeuren-Sonderbuch, Germany

Kurt Rauchle