Case Western Reserve University

Northwestern University

University of Colorado

Kurt Q Lu

Kevin D Cooper

Livia A Veress

Amisha Wallia

Disclosed herein are methods and compositions useful in reducing inflammation, reducing inflammatory exudates, enhancing epithelial tissue generation or regeneration, and/or reducing mean pulmonary artery pressure in the lungs of a subject in need thereof. In particular, the compositions comprise vitamin D, an analog, or metabolite thereof, and the methods include administering the composition to a subject in need thereof. In some embodiments, the subject is suffering from an infection, such as a viral infection, which affects the lungs. In some embodiments, the viral infection comprises SARS-CoV-2.

Vitamin D as an immune modulator to prevent immune-related complication from COVID-19 infection

A method of generating a hyper iNOS expressing cell includes administering to a myeloid derived cell an amount of a PPAR&#x3b3; agonist and an IL-6/STAT3 signaling pathway antagonist effective to substantially inhibit STAT3 activation in the cell and administering an inflammatory insult to the cell to stimulate hyper iNOS expression from the cell.

Methods of generating hyper INOS expressing cells and uses thereof

Methods of generating hyper iNOS expressing cells and uses thereof

Growing community of inventors

Cleveland Heights, OH, United States of America

Kurt Q Lu