Aventis Pharma Deutschland, Gmbh

Cordon Pharma International Gmbh

Corden Pharma International Gmbh

Corden Pharma Colorado, Inc.

Kurt Kesseler

Gerhard Jas

Ilia Freifeld

Richard Robert Dauer

Alexandre Clavel

The invention relates to a process for the preparation of a ketone of a general formula 1 with X being Cl or Br, in particular with X being Cl, with Y being F, Cl, Br, I or H, in particular with Y being F,comprising the steps of: activation of a carboxylic acid by using a peptide coupling agent, coupling of the activated carboxylic acid with a malonic acid derivative providing a &#x3b2;-ketoester precursor and converting the &#x3b2;-ketoester precursor to the ketone of the general formula 1.

Most effective process for base-free preparation of ketone intermediates usable for manufacture of nebivolol

The invention relates to a process for producing Nebivolol hydrochloride, (formula I) comprising the steps of: provision of a protected Nebivolol hydrochloride of the general formula (II), with P being an amine protecting group, and hydrogenation of said protected Nebivolol hydrochloride yielding Nebivolol hydrochloride of the formula (I).

Method for producing nebivolol hydrochloride of high purity

An ethanol solvate form of (&minus;)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8&lsqb;4R-(3S-hydroxy-1-methyl)piperidinyl&rsqb;-4H-1-benzopyran-4-one hydrochloride (Form II), a method of making Form II and a composition comprising Form II.

Ethanol solvate of (-)-cis-2-(2-chlorophenyl)-5, 7-dihydroxy-8 &lsqb;4R-(3S-hydroxy-1-M ethyl) piperidinyl&rsqb;-4H-1-benzopyran-4-one

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Hofheim, Germany

Kurt Kesseler