Astrazeneca Ab

Kurt-Jürgen Hoffmann

Gert Strandlund

Peder Svensson

Magnus Björsne

Annika Björe

Fritiof Pontén

Michael Wilsterman

David Gustafsson

David Cladingboel

John Pavey

Thomas Antonsson

Jan-Erik Nyström

Colin Thomson

Michael Wilstermann

Magnus Bjorsne

Annika Björ

Torbjörn Halvarsson

Bertil Samuelsson

Henrik Sörensen

Fritiof Pontėn

Mikael Sellén

There is provided compounds of formula I, wherein R, R, R, R, Rto R, A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.

Oxabispidine compounds useful in the treatment of cardiac arrhythmias

There is provided compounds of formula I,RO(O)C&#x2014;CH&#x2014;(R)Cgl-Aze-Pab-RIwherein Rand Rhave meanings given in the description, which are useful as prodrugs of inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (eg thrombosis) or as anticoagulants.

Prodrugs of thrombin inhibitors

There is provided compounds of formula (I), wherein R, Rand Rto Rhave meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.

3,8-Diazabicyclo[3.2.1]octanes and their use in the treatment of cardiac arrhythmias

There is provided compounds of formula I,wherein R, R, R, R, R, R, R, X, A, B and D have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.

Bispidine compounds useful in the treatment of cardiac arrythmias

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Kullavik, Sweden

Kurt-Jürgen Hoffmann