Anacor Pharmaceuticals, Inc.

Eli Lilly and Company

Entelos, Inc.

Kurt Jarnagin

Tsutomu Akama

Yasheen Zhou

Jacob J Plattner

Yong-Kang Zhang

Yong Zhang

William Hunter White

Georges Natsoulis

Shon Roland Pulley

David C Sullivan

Mark Fielden

Kyle Kolaja

Provided are compounds useful for controlling endoparasites both in animals and agriculture. Further provided are methods for controlling endoparasite infestations of an animal by administering an effective amount of a compound as described above, or a pharmaceutically acceptable salt thereof, to an animal, as well as formulations for controlling endoparasite infestations using the compounds described above or an acceptable salt thereof, and an acceptable carrier. The claimed compounds are described by the following Markush formula: A typical example for a compound according to above formula is: A typical example for a compound according to above formula is: 

1-hydroxy-benzooxaboroles as antiparasitic agents

Compounds, pharmaceutical formulations, and methods of treating anti-inflammatory conditions and/or helminth-associated diseases are disclosed.

Boron containing small molecules

This invention provides novel compounds of the following formula and pharmaceutical compositions containing such compounds. 

Boron-containing small molecules

This invention provides, among other things, novel compounds useful for treating inflammatory conditions, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.

The invention discloses reagent sets and gene signatures for predicting onset of renal tubule injury in a subject. The invention also provides a necessary set of 186 genes useful for generating signatures of varying size and performance capable of predicting onset of renal tubule injury. The invention also provides methods, apparatuses and reagents useful for predicting future renal tubule injury based on expression levels of genes in the signatures. In one particular embodiment the invention provides a method for predict whether a compound will induce renal tubule injury using gene expression data from sub-acute treatments.

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San Mateo, CA, United States of America

Kurt Jarnagin