Forschungszentrum Julich Gmbh

Kurt Hamacher

Christian Wandrey

Udo Kragl

Andreas Liese

Heinz Hubert Coenen

Gerrit Blessing

Willi Bolten

Thomas Tierling

Juliane Beliczey

The invention relates to a flow cell, a method for separating carrier-free radionuclides from a liquid or liquefiable target material, and the radiochemical reaction thereof. According to prior art, flow cells are known which require reaction volumes corresponding to the volume of the target material in order to carry out the desired reactions. The inventive flow cell () and method enable the reaction volume, and thus the quantity of starting material, to be reduced by a multiple by reducing the cylinder volume (=reaction volume). As the radioactively marked product is present in very small quantities (picomole to nanomole), the HPL-chromatographic separation of the non-reacted starting material is significantly improved. The economic efficiency of the method is increased due to the fact that small quantities of starting material can be used.

Flow cell, method for separating carrier-free radionuclides, and the radiochemical reaction thereof

The compound O-(2-[F]fluoroethyl)-L-tyrosine has proven to be particularly suitable for positron emission tomography and has already been tested in clinical practice. Until now, the compound has been prepared according to a relatively laborious method (Wester H. J. et al., J. Nucl. Med. 1999; 40: 205-212). The invention relates to L-tyrosine derivatives of the formula (1)whereby Rrepresents a suitable protective group for the carboxy group, Ra suitable protective group for the amino group and Ra suitable leaving group, The invention also relates to a method for preparing O-(2-[F]-fluoroethyl)-L-tyrosine from the initial compounds of formula (1) and method for the preparation of these initial compounds.

Protected tyrosine derivatives, method for the production thereof and use of the same for producing o-(2-[18f]-fluoroethyl)-l-tyrosine

Furanosides or pyranosides can be reacted with pyruvate and converted into sialic acids in good yields by an enzymatic synthesis, using a suitable aldolase, where the concentration of aldolase, per 50 mM of pyruvate, is 1 to 2,500 U*/ml. For example, 3-fluoroneuraminic acid and other 3,3-didesoxy-3-fluorononulopyranosonic acid derivatives can be prepared in this manner. The F-atom in the resulting sialic acid (which can be F or F and F) provides a label which makes possible studies of mammalian physiology and diagnosis of mammalian diseases.

Method for making fluorinated sugars having a side chain and use thereof

Process for the separation of carrier-free radio-nuclides from target

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Aachen, Germany

Kurt Hamacher