Other

Bioflexin Ab

Procur Ab

Glycorex Transplantation Ab

Procur Aktiebolag

Pharmacia Fine Chemicals Ab

Svenska Sockerfabriks Ab

Glycorex Ab

Kurt G Nilsson

Carl-Fredrik Mandenius

Klaus H Mosbach

Lars-&angst;ke Larsson

Åsa Kronblad

Apparatus for contacting body fluids with the bio-affinity material is disclosed. The apparatus includes a container having top and bottom lock covers that clip onto the container.

Device for bio-affinity material

Material characterized by that the material contains at least one biologically active di- or trisaccharide or higher oligosaccharide which is covalently bound via a spacer to cross-linked agarose.

Filtration material

A biosensor in which a carbohydrate or a derivative of a carbohydrate is used to generate a detectable signal by way of the specific binding to a protein, a virus or a cell.

Immobilized carbohydrate biosensor

The present invention relates to simplified synthesis, new carbohydrate-based products and practical use of different carbohydrate-based products. Examples of these are (Gal&#x3b1;1-3Gal), GlcNAc&#x3b2;1-3Gal, &#x3b1;- or &#x3b2;-glycosides thereof, Gal&#x3b1;1-3Gal- containing tri-, or higher oligosaccharides, &#x3b1;- or &#x3b2;-glycosides thereof, GlcNAc&#x3b2;1-3Gal containing tri-, tetra-, or higher oligosaccharides, and derivatives and/or &#x3b1;- or &#x3b2;-glycosides thereof, Gal&#x3b1;1-3GalGlcNAc&#x3b2;1-3Gal, &#x3b1;- or &#x3b2;-glycosides thereof, Gal&#x3b1;1-3Gal&#x3b2;1-4GlcNAc&#x3b2;1-3Gal&#x3b2;1-4Glc, or other higher oligosaccharides containing the Gal&#x3b1;1-3Gal-structure, &#x3b1;- or &#x3b2;-glycosides thereof, modified carbohydrates, di-, tri-, oligo-, or polyfunctional products containing carbohydrate structures, and the use of the products for synthesis, affinity purification, diagnostic applications and therapy.

Galactopyranosides and their use

The present invention refers to a biosensor in which an immobolized carbohydrate or a derivative thereof is used to generate a detectable signal when a protein, a virus or a cell is bound to the carbohydrate surface. The sensor is an optical sensor, a piezoelectric sensor, an electrochemical electrode or a thermistor. A method of binding carbohydrates to a gold surface is also described.

Material characterized by that the material contains at least one biologically active saccharide which is covalently bound via at least one spacer to a crosslinked matrix.

Material

Disclosed is a method of producing a compound with &bgr;1-4 linkage which contains the lactosamine structure involving reacting at least one donor substance Gal&bgr;OR where R is an organic group, and at least one acceptor substance which is a glucopyranosamino derivative having the formula GlcNR&Prime;&mdash;R&prime;&Prime;, wherein NR&Prime; is an azido, 2-N-acetyl-, 2-N-phtalimido, or an organic group bound to the 2-N-group of glucosamine, wherein R&prime;&Prime; is a glycosidically bound fluoro or is an O-, C-, N- or S-glycosidically bound aliphatic or aromatic compound, with the proviso that if NR&Prime; is NHAc then R&prime;&Prime; is not OH and if NR&Prime; is not NHAc then R&prime;&Prime; may be OH, in the presence of or an E.C. group 3.2 glycosidase of essentially the same structure as an E.C. Group 3.2 glycosidase obtained from to form the lactosamine derivative; and optionally isolating the compound with &bgr;1-4 linkage which contains the lactosamine structure.

Method of producing derivatives of lactosamine

Column for elimination of plasma components

The present invention relates to simplified synthesis, new carbohydrate-based products and practical use of different carbohydrate-based products. Examples of these are (Gal&agr;1-3Gal), GlcNAc&bgr;1-3Gal, &agr;- or &bgr;-glycosides thereof, Gal&agr;1-3Gal- containing tri-, or higher oligosaccharides, &agr;- or &bgr;-glycosides thereof, GlcNAc&bgr;1-3Gal containing tri-, tetra-, or higher oligosaccharides, and derivatives and/or &agr;- or &bgr;-glycosides thereof, Gal&agr;1-3GalGlcNAc&bgr;1-3Gal, &agr;- or &bgr;-glycosides thereof, Gal&agr;1-3Gal&bgr;1-4GlcNAc&bgr;1-3Gal&bgr;1-4Glc, or other higher oligosaccharides containing the Gal&agr;1-3Gal-structure, &agr;- or &bgr;-glycosides thereof, modified carbohydrates, di-, tri-, oligo-, or polyfunctional products containing carbohydrate structures, and the use of the products for synthesis, affinity purification, diagnostic applications and therapy.

Method of producing derivatives of Glc-.beta. 1-4Glc-N-acetyl

Synthesis of an amino-disaccharide, amino-oligosaccharide or a derivative thereof, characterized in that a monosaccharide, a disaccharide, an oligosaccharide, a glycoside or a derivative thereof, in the presence of a glycosidase as catalyst, is reacted with an amino-deoxy-saccharide or a derivative thereof, and that the amino-saccharide is isolated from the product mixture directly or after chemical/enzymatic modification.

Growing community of inventors

Lund, Sweden

Kurt G Nilsson