Basf Se Corporation

Evonik Degussa Gmbh

Codexis, Inc.

Kurt Faber

Bernhard Hauer

Rainer Stürmer

Wolfgang Kroutil

Melanie Hall

Clemens Stückler

Thomas Haas

Birgit Kosjek

Thomas Friedrich

Stephan Maurer

Jürgen Eck

Anja Thiessenhusen

Frank Niehaus

Melanie Bonnekessel

Thomas Buelter

Steffen Maurer

Stefan Gilch

Alexander Dennig

Bettina M Nestl

Silvia Glück

Barbara Schnell

Monika Pirker

Christian Gruber

Wolfgang Stampfer

The present invention provides a microbial cell capable of producing at least one terminal alkene from at least one short chain fatty acid, wherein the cell is genetically modified to comprise

Alkene production

A process for the enzymatic reduction of an enoate (1) wherein the C&#x2550;C bond of the enoate (1) is stereoselectively hydrogenated in the presence of an enoate-reductase and an oxidizable co-substrate (2) in a system which is free of NAD(P)H, in which A is a ketone radical (&#x2014;CRO), an aldehyde radical (&#x2014;CHO), a carboxyl radical (&#x2014;COOR), with R&#x2550;H or optionally substituted C-C-alkyl radical, R, Rand Rare independently of one another H, &#x2014;O&#x2014;C-C-alkyl, &#x2014;O&#x2014;W with W=a hydroxyl protecting group, C-C-alkyl, which can be substituted, C-C-alkenyl, carboxyl, or an optionally substituted carbo- or heterocyclic, aromatic or nonaromatic radical, or one of R, Rand Ris a &#x2014;OH radical, or Ris linked to Rso as to become part of a 4-8-membered cycle, or Ris linked to R so as to become part of a 4-8-membered cycle, with the proviso that R, Rand Rmay not be identical.

Process for the enzymatic reduction of enoates

The present invention relates to a novel enzymatically catalyzed method for the production of asymmetric aromatic aldehydes in an aqueous reaction medium containing certain organic co-solvents.

Process for the reduction of cinnamaldehyde derivative employing enoate reductases

A method for enzymatic preparation of compounds of the general formula (2) from unsaturated alkene derivatives of the general formula (1) by reducing a compound of the formula (1) in the presence of a reductase, comprising at least one of the polypeptide sequences SEQ ID NO: 1, 2 or 3 or having a functionally equivalent polypeptide sequence which is at least 80% identical to SEQ ID NO: 1, 2 or 3.

Process for enzymatic reduction of alkene derivatives

A process for the racemization of an optically active alpha-hydroxyketone by incubating said alpha-hydroxyketone in the presence of an acetoin racemase of

Biocatalytic racemisation of alpha-hydroxyketones

The present invention relates to a method for the microbiological isomerization of alpha-hydroxycarboxylic acids using an alpha-hydroxycarboxylic acid racemase, the enzymes used for this method and microorganisms which express a suitable racemase activity, a screening method for microorganisms with alpha-hydroxycarboxylic acid racemase activity, the nucleic acid sequences encoding this enzyme, expression vectors, recombinant microorganisms which express this racemase, and methods for the production or isolation of a protein with alpha-hydroxycarboxylic acid racemase activity.

Method for the microbiological isomerisation of alpha-hydroxy carboxylic acids

A method for racemizing optically active secondary alcohols by incubating these alcohols with at least one alcohol dehydrogenase of the E.C. 1.1.1. class.

Process for the racemization of optically active secondary alcohols with the use of two alcohol dehydrogenases

The invention relates to biocatalysts showing alcohol dehydrogenase activity obtainable from, their preparation, their use in the oxidation of secondary alcohols and/or the reduction of ketones, as well as nucleic acids coding for these alcohol dehydrogenases and microorganisms transformed with nucleic acids coding for these biocatalysts and their use for producing the biocatalyst or oxidizing secondary alcohols and/or reducing ketones.

Alcohol dehydrogenases with increased solvent and temperature stability

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Graz, Austria

Kurt Faber