Abbvie Biotherapeutics Inc.

Eos Biotechnology, Inc.

Schering Corporation

Protein Design Labs, Inc.

Abbvie Inc.

Affymetrix, Inc.

Pdl Biopharma, Inc.

Other

Princeton University

Abbott Biotherapeutics Corp.

Kurt C Gish

David H Mack

Keith E Wilson

Wei W Wang

Thomas J Schall

Albert Zlotnik

Jonathan A Hickson

Susan Elizabeth Morgan-Lappe

Alain Vicari

James W Purcell

Han K Kim

Louie Naumovski

Debbie Law

Maureen Elizabeth Murphy

Terrill K McClanahan

David J Balaban

Arnold J Levine

Wolfgang Seghezzi

Emma M Lees

Josie Dai

Elina Khurgin

Jim Snyder

Frances Shanahan

Arnold L Levine

Edward Yat Wah Tom

Edward Yat Tom

The present disclosure provides antibodies, antibody binding fragments, and antibody drug conjugates that bind human LRRC15, their methods of making, and their uses to treat patients having cancer.

Anti-huLRRC15 antibody drug conjugates and methods for their use

The present disclosure provides antibodies and antibody drug conjugates that bind human CS1 and their uses to treat subjects diagnosed with a plasma cell neoplasm, for example, multiple myeloma.

Anti-CS1 antibodies and antibody drug conjugates

Described herein are methods and compositions that can be used for diagnosis and treatment of cancer.

Compositions against cancer antigen LIV-1 and uses thereof

Described herein are genes whose expression are up-regulated or down-regulated in ovarian cancer. Related methods and compositions that can be used for diagnosis and treatment of ovarian cancer are disclosed. Also described herein are methods that can be used to identify modulators of ovarian cancer.

Methods of diagnosis of ovarian cancer, compositions and methods of screening for modulators of ovarian cancer

Novel chemokines from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said chemokines. Chemokine receptors are also provided. Methods of using said reagents and diagnostic kits are also provided.

Chemokine TECK polypeptides

Methods for using chemokine teck

Described herein are methods that can be used for diagnosis and prognosis of breast cancer. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate breast cancer. Additionally, methods and molecular targets (genes and their products) for therapeutic intervention in breast cancer are described.

Methods of diagnosing breast cancer

Described herein are methods that can be used for diagnosis and prognosis of colorectal cancer. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate colorectal cancer. Additionally, methods and molecular targets (genes and their products) for therapeutic intervention in colorectal and other cancers are described.

Methods of diagnosing of colorectal cancer, compositions, and methods of screening for colorectal cancer modulators

Growing community of inventors

Piedmont, CA, United States of America

Kurt C Gish