Intezyne Technologies, Incorporated

University of Massachusetts

University of Texas System

Kurt Breitenkamp

Kevin N Sill

Habib Skaff

Todd Emrick

Rebecca Breitenkamp

Benny D Freeman

Bryan D McCloskey

Ravindra Revanur

The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same.

Hybrid block copolymer micelles with mixed stereochemistry for encapsulation of hydrophobic agents

Polymeric micelles for drug delivery

The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of biologically active molecules. The invention also provides methods of using said compounds and compositions thereof.

Poly(ethylene glycol) containing chemically disparate endgroups

Compositions comprising polymeric micelles for drug delivery

The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and methods of preparing the same.

Synthesis of hybrid block copolymers and uses thereof

Azide functionalized peptide targeting groups

The present invention relates to the field of polymer chemistry and more particularly to encapsulated contrast agents and methods for using the same.

Encapsulated contrast agents

Heterobifunctional poly(ethylene glycol) containing acid-labile amino protecting groups and uses thereof

Azidoaryl-substituted cyclooctene monomers and synthesized and used in the preparation of various copolymers. Among these copolymers are those prepared from ring-opening metathesis polymerization of cyclooctene, polyethylene glycol-substituted cyclooctene, and azidoaryl-substituted cyclooctene. These copolymers are useful in the formation of crosslinked films that reduce fouling of water purification membranes.

Process of forming crosslinked copolymer film, crosslinked copolymer film formed thereby, and water purification membrane

The present invention provides modified metal surfaces, methods of preparing the same, and intermediates thereto. These materials are useful in a variety of applications including biomaterials.

Covalent modification of metal surfaces

Polymer capsules from amphiphilic graft copolymers comprising reactive, hydrophobic polyolefin backbones, and hydrophilic poly(ethylene glycol) (PEG) grafts are produced by self-assembly of the polymers at the oil-water interface, and crosslinking the assembly with bis-cyclooctene PEG derivatives in conjunction with ring-open metathesis polymerization catalysts. The use of the graft copolymer architecture in capsule synthesis provides significant opportunities to tune both the surface properties, in terms of recognition, and the membrane properties, in terms of mechanical strength, encapsulation, and release.

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San Diego, CA, United States of America

Kurt Breitenkamp