National Taipei University of Technology

National Defense Medical Center

Kuo-Yuan Hwa

Ann Chen

Wen-Liang Chang

Shuk-Man Ka

Kuo-Feng Hua

Chen-Wen Yao

An-Rong Lee

Wen-Hsin Huang

Kuo-Ping Chao

Chi-Hong Chu

Yu-May Lee

Yeh-Long Chen

Cherng-Chyi Tzeng

Hsin-Yuan Cho

Chiao-Ying Chien

Chien-Yi Pai

Disclosure of the present invention relates to a method for synthesis of a xylose derivative, which comprises protecting a xylose with a protective group, followed by incorporating to a halogen atom as a leaving group; removing the protective groups and using water-soluble ligands to carry out a Suzuki cross-couplings reaction with a palladium catalyst in a water solution. Ten new xylose derivatives as obtained by the method are also provided.

Xylose derivatives and process for preparation thereof

The present invention relates to a new use of citral for manufacturing a medicament for treating focal segmental glomerulosclerosis (FSGS). Particularly, the present invention discloses that citral is effective in alleviating symptoms of FSGS, including reducing glomerular epithelial hyperplasia lesions (EPHLs), peri-glomerular inflammation or glomerular hyalinosis or sclerosis, and also reducing proteinuria or hematuria or lowering serum urea nitrogen level or serum creatinine level in the subject.

Use of citral for treating focal segmental glomerulosclerosis

Provided is a quinoline derivative of Chemical Formula (I): 

Quinoline derivatives and uses of the same

Disclosed are an Schisandrae fructus extract for inhibition or prevention of influenza and its application, wherein the Schisandrae fructus extract is obtained by water, methanol, or ethanol extraction process and the extract comprises compounds such as schisandrone, benzoylgomisin P, wulignan A1, epigomisin O, epiwulignan A1, and tigloylgomisin P. The extracts and purified compounds of Schisandrae fructus has anti-influenza virus H1N1 and H1N1-TR (a Tamiflu drug resistant virus strain) activities, therefore the extracts and the purified compounds of Schisandrae fructus can be applied as an inhitibory agent of a pharmaceutical composition for treatment or prevention agent for influenza infection.

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Taipei, Taiwan

Kuo-Yuan Hwa