British Columbia Cancer Agency Branch

The University of British Columbia

Triumf, a Joint Venture

Provincial Health Services Authority

Kuo-shyan Lin

François Bénard

Paul Schaffer

David Perrin

Zhibo Liu

Jinhe Pan

Stefan Zeisler

Zhengxing Zhang

Stefan K Zeisler

Hsiou-ting Kuo

Aron Roxin

Mathieu Lepage

Maral Pourghiasian

Felix Mesak

Milan Vuckovic

This disclosure relates to novel compounds comprising a zwitterionic trifluoroborate prosthetic group which target prostate-specific membrane antigen (PSMA), e.g. in prostate cancer. The compounds have Formula I, wherein each R1 is an anionic group, L is a linker and R2B-F3 is &#x2014;N(R)CHBF, a pyridinium group substituted with BFor methyl BF, or an azole group substituted with methyl BF3. Methods and uses of imaging and treating PSMA-expressing cancers are also disclosed. 

18/19F-labelled compounds which target the prostate specific membrane antigen

Somatostatin derivative compounds of general formula (I) that may be readily labelled with the isotope fluorine-18 and that have affinity and selectivity for cellular somatostatin receptors are provided. The labelled compounds are useful clinically as radioactive tracers in various in vivo imaging applications (for example, using positron emission tomography (PET) and related techniques) to detect somatostatin-expressing cells and tissues, including tumors, or as therapeutic agents.

Compositions and methods for imaging cancer

Bradykinin B1 receptor (B1R) targeting peptides and compounds are radiolabelled with radioisotopes that are suitable for imaging and/or radiotherapy. The radiolabelled peptides and compounds have utility in imaging tissues expressing or overexpressing B1R and/or treating diseases or conditions in which B1R is expressed or overexpressed, including cancer.

Compositions targeting bradykinin receptor B1 for medical imaging of cancer and other disorders

Systems and methods for separation or isolation of technetium radioisotopes from aqueous solutions of radioactive or non-radioactive molybdate salts using a polyalkyl glycol-based cross-linked polyether polymer. Some embodiments can be used for the effective purification of radioactive technetium-99m produced from low specific activityMo.

Process and apparatus for separation of technetium-99M from molybdate

Growing community of inventors

Surrey, Canada

Kuo-shyan Lin