China Medical University

Kuo-Ching Wen

Hsiu-Mei Chiang

Yueh-Hsiung Kuo

A method for anti-oxidation, inhibiting the activity of matrix metalloproteinase (MMP), inhibiting the expression of matrix metalloproteinase, and/or promoting the expression of collagen in a mammal is provided, and the method comprises administrating an effective amount of anleaf extract to the mammal.

[object Object]

A method for anti-skin aging, especially for anti-skin photo-aging in a subject is provided. The method comprising administering to the subject an effective amount of an active component selected from the group consisting of a caffeamide derivative of formula (I), a pharmaceutically acceptable salt of the caffeamide derivative, and a combination thereof: wherein A is H or an alkyl; B is &#x2014;[CH2]&#x2014;; m is an integer ranging from 0 to 10; R1 is H, an optionally substituted phenyl, an optionally substituted pyridyl, &#x2014;OH, or &#x2014;OCH; or, N, A, B, and R1 together form an optionally substituted pyrrolyl or piperidyl.

Method for anti-skin aging using caffeamide derivative

A method for inhibiting at least one selected from the group consisting of oxidation, the activity of matrix metalloproteinase (MMP), the expression of matrix metalloproteinase, and the phosphorylation of mitogen-activated protein kinase (MAP kinase) in a mammal, comprising administrating to the mammal an effective amount of aextract.

Method for anti-oxidation, inhibiting activity and/or expression of matrix metalloproteinase, and/or inhibiting phosporylation of mitogen-activated protein kinase using flemingia macrophylla extract

A method of inhibiting at least one selected from the group consisting of oxidation, the activity of matrix metalloproteinase (MMP), the expression of matrix metalloproteinase, and the phosphorylation of mitogen-activated protein kinase (MAP kinase) in a mammal, comprising administrating to the mammal an effective amount of aleaf extract, is provided.

Method for anti-oxidation, inhibiting activity and/or expression of matrix metalloproteinase, and/or inhibiting phosphorylation of mitogen-activated protein kinase using neonauclea reticulata leaf extracts

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Taichung, Taiwan

Kuo-Ching Wen