Chinese Pla General Hospital

Kunluu He

Wei Li

Xin Li

Lili Wang

Jie Tang

Song Li

Wu Zhong

Jie Wang

Junhai Xiao

Zhibing Zheng

Juan Liu

Long Long

Guoliang Hu

Chunlei Liu

Ruijun Li

The present invention relates to a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate of the compound, and to a composition comprising the compound of Formula I, or the isomer, pharmaceutically acceptable salt and solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluents. The present invention also relates to use of the compound of Formula I, or the isomer, pharmaceutically acceptable salt and solvate thereof for combating apoptosis, preventing or treating a disease or disorder associated with apoptosis; and especially use for protecting cardiomyocyte, and for preventing or treating a disease or disorder associated with cardiomyocyte apoptosis. 

Acrylamide compounds and use thereof for inhibiting apoptosis

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Beijing, China

Kunluu He