Linhai Tianyu Pharmaceutical Co., Ltd.

Shanghai Qixun Pharmaceutical Technology Co., Ltd.

Kunlun Qiu

Wenbo Wang

Xiongdong Lian

Botao Li

Gongyong Li

Qianjie Yu

Disclosed is a method for preparing a 2-fluoroacrylate, comprising the steps of: (1) mixing a vinyl ether having the structure of formula A with dichloromonofluoromethane to yield a substituted cyclopropane compound having the structure of formula B; (2) mixing the substituted cyclopropane compound having the structure of formula B with ROH to yield an acetal product having the structure of formula C, followed by hydrolysis to yield 2-fluoroacrylaldehyde having the structure of formula D; or reacting the substituted cyclopropane compound having the structure of formula B with water to yield 2-fluoroacrylaldehyde having the structure of formula D via hydrolysis; (3) oxidizing 2-fluoroacrylaldehyde having the structure of formula D to yield 2-fluoroacrylic acid having the structure of formula E; and (4) mixing 2-fluoroacrylic acid having the structure of formula E with ROH to yield a 2-fluoroacrylate having the structure of formula F.

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Shanghai, China

Kunlun Qiu