Zeria Pharmaceutical Co., Ltd.

Kuniyoshi Ogura

Tomoji Aotsuka

Yoshiaki Tanaka

Naoyoshi Miura

Motoki Torizuka

Naoki Nakata

Hisayoshi Kato

Mitsuo Soeda

Naomi Kobayashi

Heihachiro Arai

Akihiro Okubo

Masao Seiki

Hiromi Ichikawa

Yoshiaki Muto

Hikari Morita

Toshihiko Takemasa

Noaki Nakata

Hikaru Morita

Kyoji Chaki

Trialkylamine derivative and ameliorant for digestive tract movement

Phenylalkanoylamine derivatives, process for preparing the same, and

Novel condensed benzene derivatives having prolyl endopeptidase inhibitory, anti-hypoxic, and anti-amnesic activities are disclosed. The compounds are represented by the following (I), ##STR1## wherein A represents a methylene, ethylene, or propylene group, B represents a methylene or ethylene group, m denotes an integer of 0-5, X and Y, which may be same or different, individually represent a methylene group or sulfur atom, R.sup.1 represents a hydrogen atom, a carboxyl, lower alkyloxycarbonyl, hydroxymethyl, or formyl group, R.sup.2 represents a hydrogen atom, a halogen atom, a lower alkyl, lower alkoxy, nitro, or amino group, R.sup.3 represents a hydrogen atom or a lower alkyl group, and the dotted line may optionally be present. They are useful as a medicine for treating or preventing cerebral circulation disorder, cerebral metabolism disorder, or memory disturbance.

Condensed benzene derivative

Novel N-substituted amino acid imide derivatives are disclosed. The compounds are represented by formula (I): ##STR1## wherein n represents an integer of 0 to 5, and X and Y, which may be the same or different, represent a methylene group or a sulfur atom, provided that not both X and Y are methylene groups at the same time. The compounds are useful as a medicine for treating or preventing cerebral circulation disorder, cerebral metabolism disorder, or memory disturbance.

Amino acid imide derivatives, usage thereof, and medicinal composition

Growing community of inventors

Konan, Japan

Kuniyoshi Ogura