Kureha Chemical Industry Company, Limited

Kureha Kagaku Kogyo Kabushiki Kaisha

Kureha Corporation

Kunitaka Hirose

Toru Yamazaki

Mikiro Yanaka

Kenichi Matsunaga

Chikao Yoshikumi

Masahiro Ono

Koichi Niimura

Shigeru Suzuki

Masaaki Takahashi

Takao Furusho

Shigeaki Muto

Yoshiharu Oguchi

Shigeyuki Kikumoto

Ryo Matsui

Atsushi Saitou

Haruka Takahashi

Sei Kumakura

Norifumi Sugita

Junji Kakuchi

Minoru Oohara

Yoshiyuki Takemura

Jun Sakai

Naoki Yamamoto

Kouji Matsushima

Hiroshi Maruoka

Kouji Kuno

Michinori Hakozaki

Eiji Inoguchi

Keiko Ishioka

Yukako Ishida

Tsutomu Mukade

It is intended to provide novel amine compounds which are efficacious against diseases such as infection with HIV virus, rheumatism and cancer metastasis. Namely, amine compounds represented by the following general formula (1):  In a typical case, A1 and A2 represent each an optionally substituted monocyclic or polycyclic aromatic heterocycle; W represents cyclic C3-10 alkylene, an optionally substituted monocyclic or polycyclic aromatic heterocycle, a monocyclic or polycyclic aromatic ring or a partly saturated polycyclic aromatic ring; X represents O, CH2, C(&#x2550;O) or NR11; and D is a group represented by the following general formula (4) or (6).  In the formula (6), Q represents a single bond, S, O or NR12; and Y is a group represented by the following general formula (7). z represents an optionally substituted monocyclic or polycyclic aromatic ring. In the formula (6), B represents NR25R26. In the above formulae, R1 to R26 each represents hydrogen, alkyl, alkenyl or alkynyl.

Amine compound and use thereof

Novel amine compounds which are efficacious against diseases such as infection with HIV virus, rheumatism, and cancer metastasis include compounds represented by the following general formula (1), a pharmacologically acceptable salt thereof, or a prodrug thereof: wherein each of n, n, and nis an integer of 1; each of R, R, R, R, R, and Ris independently a hydrogen atom; Ais imidazole; Ais imidazole or imidazole substituted with an alkyl group; W is a phenyl group or naphthyl group; X is CH; D is a group represented by -Q-Y&#x2014;B, wherein Q is NRand Ris a hydrogen atom or an alkyl group; Y is (CH)mand mis an integer of 2 to 4; and B is N(RR), wherein each of Rand Rare independently a hydrogen atom, a C&#x2013;Calkyl group or a C&#x2013;Ccycloalkyl group.

Amine compounds and use thereof

Novel proteins, novel genes encoding the same, plasmids respectively comprising these genes, transformants respectively comprising these plasmids, antibodies or fragments thereof against the above novel proteins, methods of detecting a bacterial infection, and novel polynucleotides are disclosed. The novel proteins are activated human macrophage-specific proteins.

Proteins and novel genes encoding the same

The present invention provides novel compounds having antiviral activities and antiviral drugs containing the compounds as the active ingredient. The compounds are shown by the following general formula (1),wherein typically Aand Aare each guanidine or a group of the general formula (ia); Ais a mono- or poly-cyclic heteroaromatic ring containing 1 or 2 heteroatoms; Bis a single bond or alkylene group; Ris hydrogen or alkyl group; W is an alkylene having 2-3 carbons, a cycloalkylene having 5-10 carbons, aromatic ring having 6-10 carbons, or a heteroaromatic ring having 5-10 carbons; y is C(&#x2550;O)&#x2014;; x is &#x2014;C(&#x2550;O)&#x2014;NH&#x2014;; nis an integer of 1-2; nis an integer of 2-3; D is a substituent selected from among various groups

Nitrogenous compounds and antiviral drugs containing the same

A human ADAMTS-1 protein, a gene encoding the same, a pharmaceutical composition containing the protein as an active ingredient, and a method for immunologically analyzing the human ADAMTS-1 protein are disclosed. The protein can decrease the number of leukocytes and platelets, and at the same time, increase the number of erythrocytes.

Human ADAMTS-1 protein and pharmaceutical composition

Disclosed herein are polysaccharides extracted from marine algae and an antiviral drug containing as active ingredient polysaccharides extracted from seaweeds.

Polysaccharides and antiviral drugs containing the same as active

Disclosed herein are lectins extracted form a plant of the class Dicotyledoneae and an antiretoviral drug comprising as an active ingredient an effective amount of the lectins.

Lectins and antiretroviral drugs containing the lectins as active

Growing community of inventors

Tokyo, Japan

Kunitaka Hirose