Teijin Limited

National Cancer Center

Rational Drug Design Laboratories

Kunitada Shimotohno

Yataro Ichikawa

Tsuto Morinaga

Kin-ichiro Miura

Masato Ikegami

Torahiko Tanaka

Nobuyuki Katoh

An objective of this invention is to clarify the sequence of the 3'-end site of HCV genome and to provide a new process for detecting HCV. A new sequence with a highly conserved 3'-end site of the HCV genome has been found. Using the said sequences, new process for detecting HCV, a process for inhibiting proliferation of HCV, etc. have been provided.

Nucleic acid of C type hepatitis virus derivation and process for

Double-stranded DNA characterized by having sequences complementary to a single-stranded DNA which has a molecular size of about 2.67 Kb and is derived from mungbean yellow mosaic virus, and giving the restriction endonuclease cleavage map shown in FIG. 1 of the accompanying drawings; and double-stranded DNA characterized by having sequences complementary to a single-stranded DNA which has a molecular size of about 2.70 Kb and is derived from mungbean yellow mosaic virus, and giving the restriction endonuclease cleavage map shown in FIG. 2 of the accompanying drawings; and hybrid DNAs having the double-stranded DNAs inserted thereinto.

Double-stranded DNA having sequences complementary to a single-stranded

Double-stranded DNA characterized by having sequences complementary to a single-stranded DNA which has a molecular size of about 2.67 Kb and is derived from mungbean yellow mosaic virus, and giving the restriction endonuclease cleavage map shown in FIG. 1 of the accompanying drawings; and

Growing community of inventors

Tokyo, Japan

Kunitada Shimotohno