Chugai Seiyaku Kabushiki Kaisha

Kunio Tamura

Yoshiaki Kato

Osamu Cynshi

Akira Ishikawa

Yasuhiro Ohba

Mitsutaka Yoshida

Yoshiaki Takashima

Masahiro Shimizu

Hirohito Shimizu

An industrially useful process for producing benzofuran derivatives of formula (1):by formylating a compound of formula (2):

Process for preparation of a benzofuran derivative

2,3-dihydrobenzofuran derivatives

Therapeutic agents for renal diseases and organ preservatives

4,6 Di-t-butyl-5-hydroxy-2,3-dihydrobenzothiophene

Compounds represented by the general formula (I), as well as intermediates for the synthesis of thereof: ##STR1## where R.sup.1 is a hydrogen atom or an acyl group; R.sup.2 is a lower alkyl group; R.sup.3 is a hydrogen atom or a lower alkyl group; R.sup.4, R.sup.5 and R.sup.6, which may be the same or different, are a hydrogen atom or an optionally substituted alkyl, alkenyl, alkynyl or aryl group; R.sup.2 and R.sup.4, when taken together, may form a 5-membered ring; R.sup.5 and R.sup.6, when taken together, may form a cycloalkyl group or a heterocyclic group in which at least one methylene on the ring of a cycloalkyl group is substituted by an oxygen atom, a sulfur atom or an alkyl-substituted nitrogen atom, provided that R.sup.6 is not present if the ring formed by R.sup.2 and R.sup.4 taken together is a benzofuran ring. The compounds represented by the general formula (I) have a highly selective anti-oxidative activity and are useful as therapeutics of ischemic diseases such as arteriosclerosis and myocardial infarction.

4-alkoxy-2, 6-di-t-butylphenol derivatives

4,6-Di-t-butyl-dihydrobenzofuran-5-ol and its derivatives

Growing community of inventors

Shizuoka-ken, Japan

Kunio Tamura